Telomerase Activation in Hematological Malignancies

Telomerase expression and telomere maintenance are critical for cell proliferation and survival, and they play important roles in development and cancer, including hematological malignancies. Transcriptional regulation of the rate-limiting subunit of human telomerase reverse transcriptase gen (hTERT...

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Detalles Bibliográficos
Autores principales: Ropio, Joana, Merlio, Jean-Philippe, Soares, Paula, Chevret, Edith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039560/
https://www.ncbi.nlm.nih.gov/pubmed/27618103
http://dx.doi.org/10.3390/genes7090061
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author Ropio, Joana
Merlio, Jean-Philippe
Soares, Paula
Chevret, Edith
author_facet Ropio, Joana
Merlio, Jean-Philippe
Soares, Paula
Chevret, Edith
author_sort Ropio, Joana
collection PubMed
description Telomerase expression and telomere maintenance are critical for cell proliferation and survival, and they play important roles in development and cancer, including hematological malignancies. Transcriptional regulation of the rate-limiting subunit of human telomerase reverse transcriptase gen (hTERT) is a complex process, and unveiling the mechanisms behind its reactivation is an important step for the development of diagnostic and therapeutic applications. Here, we review the main mechanisms of telomerase activation and the associated hematologic malignancies.
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spelling pubmed-50395602016-09-29 Telomerase Activation in Hematological Malignancies Ropio, Joana Merlio, Jean-Philippe Soares, Paula Chevret, Edith Genes (Basel) Review Telomerase expression and telomere maintenance are critical for cell proliferation and survival, and they play important roles in development and cancer, including hematological malignancies. Transcriptional regulation of the rate-limiting subunit of human telomerase reverse transcriptase gen (hTERT) is a complex process, and unveiling the mechanisms behind its reactivation is an important step for the development of diagnostic and therapeutic applications. Here, we review the main mechanisms of telomerase activation and the associated hematologic malignancies. MDPI 2016-09-07 /pmc/articles/PMC5039560/ /pubmed/27618103 http://dx.doi.org/10.3390/genes7090061 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ropio, Joana
Merlio, Jean-Philippe
Soares, Paula
Chevret, Edith
Telomerase Activation in Hematological Malignancies
title Telomerase Activation in Hematological Malignancies
title_full Telomerase Activation in Hematological Malignancies
title_fullStr Telomerase Activation in Hematological Malignancies
title_full_unstemmed Telomerase Activation in Hematological Malignancies
title_short Telomerase Activation in Hematological Malignancies
title_sort telomerase activation in hematological malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039560/
https://www.ncbi.nlm.nih.gov/pubmed/27618103
http://dx.doi.org/10.3390/genes7090061
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AT merliojeanphilippe telomeraseactivationinhematologicalmalignancies
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