Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass

Ataxia-telangiectasia mutated (ATM) kinase is a central component involved in the signal transduction of the DNA damage response (DDR) and thus plays a critical role in the maintenance of genomic integrity. Although the primary functions of ATM are associated with the DDR, emerging data suggest that...

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Detalles Bibliográficos
Autores principales: Hirozane, Toru, Tohmonda, Takahide, Yoda, Masaki, Shimoda, Masayuki, Kanai, Yae, Matsumoto, Morio, Morioka, Hideo, Nakamura, Masaya, Horiuchi, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039636/
https://www.ncbi.nlm.nih.gov/pubmed/27677594
http://dx.doi.org/10.1038/srep34426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039636/
https://www.ncbi.nlm.nih.gov/pubmed/27677594
http://dx.doi.org/10.1038/srep34426

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