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Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice

Cytosine methylation of DNA is an epigenetic modification involved in the repression of genes that affect biological processes including hematopoiesis. It is catalyzed by DNA methyltransferases, one of which -DNMT3A- is frequently mutated in human hematologic malignancies. We have previously reporte...

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Detalles Bibliográficos
Autores principales:	Haney, Staci L., Upchurch, Garland M., Opavska, Jana, Klinkebiel, David, Appiah, Adams Kusi, Smith, Lynette M., Heavican, Tayla B., Iqbal, Javeed, Joshi, Shantaram, Opavsky, Rene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039761/ https://www.ncbi.nlm.nih.gov/pubmed/27677595 http://dx.doi.org/10.1038/srep34222

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