Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound–Kinase Activities: A Way toward Selective Promiscuity by Design?

[Image: see text] Drug discovery programs frequently target members of the human kinome and try to identify small molecule protein kinase inhibitors, primarily for cancer treatment, additional indications being increasingly investigated. One of the challenges is controlling the inhibitors degree of...

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Detalles Bibliográficos
Autores principales: Christmann-Franck, Serge, van Westen, Gerard J. P., Papadatos, George, Beltran Escudie, Fanny, Roberts, Alexander, Overington, John P., Domine, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039764/
https://www.ncbi.nlm.nih.gov/pubmed/27482722
http://dx.doi.org/10.1021/acs.jcim.6b00122

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