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Orthostatic Tremor: An Update on a Rare Entity

BACKGROUND: Orthostatic tremor (OT) remains among the most intriguing and poorly understood of movement disorders. Compared to Parkinson’s disease or even essential tremor, there are very few articles addressing more basic science issues. In this review, we will discuss the findings of main case ser...

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Autores principales: Benito-León, Julián, Domingo-Santos, Ángela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Columbia University Libraries/Information Services 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039949/
https://www.ncbi.nlm.nih.gov/pubmed/27713855
http://dx.doi.org/10.7916/D81N81BT
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author Benito-León, Julián
Domingo-Santos, Ángela
author_facet Benito-León, Julián
Domingo-Santos, Ángela
author_sort Benito-León, Julián
collection PubMed
description BACKGROUND: Orthostatic tremor (OT) remains among the most intriguing and poorly understood of movement disorders. Compared to Parkinson’s disease or even essential tremor, there are very few articles addressing more basic science issues. In this review, we will discuss the findings of main case series on OT, including data on etiology, pathophysiology, diagnostic approach, treatment strategies, and outcome. METHODS: Data for this review were identified by searching PUBMED (January 1966 to August 2016) for the terms “orthostatic tremor” or “shaky leg syndrome,” which yielded 219 entries. We did not exclude papers on the basis of language, country, or publication date. The electronic database searches were supplemented by articles in the authors’ files that pertained to this topic. RESULTS: Owing to its rarity, the current understanding of OT is limited and is mostly based on small case series or case reports. Despite this, a growing body of evidence indicates that OT might be a progressive condition that is clinically heterogeneous (primary vs. secondary cases) with a broader spectrum of clinical features, mainly cerebellar signs, and possible cognitive impairment and personality disturbances. Along with this, advanced neuroimaging techniques are now demonstrating distinct anatomical and functional changes, some of which are consistent with neuronal loss. DISCUSSION: OT might be a family of diseases, unified by the presence of leg tremor, but further characterized by etiological and clinical heterogeneity. More work is needed to understand the pathogenesis of this condition.
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spelling pubmed-50399492016-10-06 Orthostatic Tremor: An Update on a Rare Entity Benito-León, Julián Domingo-Santos, Ángela Tremor Other Hyperkinet Mov (N Y) Reviews BACKGROUND: Orthostatic tremor (OT) remains among the most intriguing and poorly understood of movement disorders. Compared to Parkinson’s disease or even essential tremor, there are very few articles addressing more basic science issues. In this review, we will discuss the findings of main case series on OT, including data on etiology, pathophysiology, diagnostic approach, treatment strategies, and outcome. METHODS: Data for this review were identified by searching PUBMED (January 1966 to August 2016) for the terms “orthostatic tremor” or “shaky leg syndrome,” which yielded 219 entries. We did not exclude papers on the basis of language, country, or publication date. The electronic database searches were supplemented by articles in the authors’ files that pertained to this topic. RESULTS: Owing to its rarity, the current understanding of OT is limited and is mostly based on small case series or case reports. Despite this, a growing body of evidence indicates that OT might be a progressive condition that is clinically heterogeneous (primary vs. secondary cases) with a broader spectrum of clinical features, mainly cerebellar signs, and possible cognitive impairment and personality disturbances. Along with this, advanced neuroimaging techniques are now demonstrating distinct anatomical and functional changes, some of which are consistent with neuronal loss. DISCUSSION: OT might be a family of diseases, unified by the presence of leg tremor, but further characterized by etiological and clinical heterogeneity. More work is needed to understand the pathogenesis of this condition. Columbia University Libraries/Information Services 2016-09-22 /pmc/articles/PMC5039949/ /pubmed/27713855 http://dx.doi.org/10.7916/D81N81BT Text en © 2016 Benito-León et al. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommerical–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed.
spellingShingle Reviews
Benito-León, Julián
Domingo-Santos, Ángela
Orthostatic Tremor: An Update on a Rare Entity
title Orthostatic Tremor: An Update on a Rare Entity
title_full Orthostatic Tremor: An Update on a Rare Entity
title_fullStr Orthostatic Tremor: An Update on a Rare Entity
title_full_unstemmed Orthostatic Tremor: An Update on a Rare Entity
title_short Orthostatic Tremor: An Update on a Rare Entity
title_sort orthostatic tremor: an update on a rare entity
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039949/
https://www.ncbi.nlm.nih.gov/pubmed/27713855
http://dx.doi.org/10.7916/D81N81BT
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