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Ultra‐Specific Isolation of Circulating Tumor Cells Enables Rare‐Cell RNA Profiling
The clinical potential of circulating tumor cells (CTCs) in managing cancer metastasis is significant. However, low CTC isolation purities from patient blood have hindered sensitive molecular assays of these rare cells. Described herein is the ultra‐pure isolation of CTCs from patient blood samples...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039969/ https://www.ncbi.nlm.nih.gov/pubmed/27711257 http://dx.doi.org/10.1002/advs.201600063 |
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| author | Jack, Rhonda M. Grafton, Meggie M. G. Rodrigues, Danika Giraldez, Maria D. Griffith, Catherine Cieslak, Robert Zeinali, Mina Kumar Sinha, Chandan Azizi, Ebrahim Wicha, Max Tewari, Muneesh Simeone, Diane M. Nagrath, Sunitha |
| author_facet | Jack, Rhonda M. Grafton, Meggie M. G. Rodrigues, Danika Giraldez, Maria D. Griffith, Catherine Cieslak, Robert Zeinali, Mina Kumar Sinha, Chandan Azizi, Ebrahim Wicha, Max Tewari, Muneesh Simeone, Diane M. Nagrath, Sunitha |
| author_sort | Jack, Rhonda M. |
| collection | PubMed |
| description | The clinical potential of circulating tumor cells (CTCs) in managing cancer metastasis is significant. However, low CTC isolation purities from patient blood have hindered sensitive molecular assays of these rare cells. Described herein is the ultra‐pure isolation of CTCs from patient blood samples and how this platform has enabled highly specific molecular (mRNA and miRNA) profiling of patient CTCs. [Image: see text] |
| format | Online Article Text |
| id | pubmed-5039969 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-50399692016-10-03 Ultra‐Specific Isolation of Circulating Tumor Cells Enables Rare‐Cell RNA Profiling Jack, Rhonda M. Grafton, Meggie M. G. Rodrigues, Danika Giraldez, Maria D. Griffith, Catherine Cieslak, Robert Zeinali, Mina Kumar Sinha, Chandan Azizi, Ebrahim Wicha, Max Tewari, Muneesh Simeone, Diane M. Nagrath, Sunitha Adv Sci (Weinh) Communications The clinical potential of circulating tumor cells (CTCs) in managing cancer metastasis is significant. However, low CTC isolation purities from patient blood have hindered sensitive molecular assays of these rare cells. Described herein is the ultra‐pure isolation of CTCs from patient blood samples and how this platform has enabled highly specific molecular (mRNA and miRNA) profiling of patient CTCs. [Image: see text] John Wiley and Sons Inc. 2016-04-18 /pmc/articles/PMC5039969/ /pubmed/27711257 http://dx.doi.org/10.1002/advs.201600063 Text en © 2016 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Communications Jack, Rhonda M. Grafton, Meggie M. G. Rodrigues, Danika Giraldez, Maria D. Griffith, Catherine Cieslak, Robert Zeinali, Mina Kumar Sinha, Chandan Azizi, Ebrahim Wicha, Max Tewari, Muneesh Simeone, Diane M. Nagrath, Sunitha Ultra‐Specific Isolation of Circulating Tumor Cells Enables Rare‐Cell RNA Profiling |
| title | Ultra‐Specific Isolation of Circulating Tumor Cells Enables Rare‐Cell RNA Profiling |
| title_full | Ultra‐Specific Isolation of Circulating Tumor Cells Enables Rare‐Cell RNA Profiling |
| title_fullStr | Ultra‐Specific Isolation of Circulating Tumor Cells Enables Rare‐Cell RNA Profiling |
| title_full_unstemmed | Ultra‐Specific Isolation of Circulating Tumor Cells Enables Rare‐Cell RNA Profiling |
| title_short | Ultra‐Specific Isolation of Circulating Tumor Cells Enables Rare‐Cell RNA Profiling |
| title_sort | ultra‐specific isolation of circulating tumor cells enables rare‐cell rna profiling |
| topic | Communications |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039969/ https://www.ncbi.nlm.nih.gov/pubmed/27711257 http://dx.doi.org/10.1002/advs.201600063 |
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