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Regulatory Mechanisms of the Molecular Pathways in Fibrosis Induced by MicroRNAs

OBJECTIVE: MicroRNAs (miRNAs or miRs) play critical roles in the fibrotic process in different organs. We summarized the latest research progress on the roles and mechanisms of miRNAs in the regulation of the molecular signaling pathways involved in fibrosis. DATA SOURCES: Papers published in Englis...

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Autores principales: Yang, Cui, Zheng, Si-Dao, Wu, Hong-Jin, Chen, Shao-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040024/
https://www.ncbi.nlm.nih.gov/pubmed/27647197
http://dx.doi.org/10.4103/0366-6999.190677
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author Yang, Cui
Zheng, Si-Dao
Wu, Hong-Jin
Chen, Shao-Jun
author_facet Yang, Cui
Zheng, Si-Dao
Wu, Hong-Jin
Chen, Shao-Jun
author_sort Yang, Cui
collection PubMed
description OBJECTIVE: MicroRNAs (miRNAs or miRs) play critical roles in the fibrotic process in different organs. We summarized the latest research progress on the roles and mechanisms of miRNAs in the regulation of the molecular signaling pathways involved in fibrosis. DATA SOURCES: Papers published in English from January 2010 to August 2015 were selected from the PubMed and Web of Science databases using the search terms “microRNA”, “miR”, “transforming growth factor β”, “tgf β”, “mitogen-activated protein kinase”, “mapk”, “integrin”, “p38”, “c-Jun NH(2)-terminal kinase”, “jnk”, “extracellular signal-regulated kinase”, “erk”, and “fibrosis”. STUDY SELECTION: Articles were obtained and reviewed to analyze the regulatory effects of miRNAs on molecular signaling pathways involved in the fibrosis. RESULTS: Recent evidence has shown that miRNAs are involved in regulating fibrosis by targeting different substrates in the molecular processes that drive fibrosis, such as immune cell sensitization, effector cell activation, and extracellular matrix remodeling. Moreover, several important molecular signaling pathways involve in fibrosis, such as the transforming growth factor-beta (TGF-β) pathway, mitogen-activated protein kinase (MAPK) pathways, and the integrin pathway are regulated by miRNAs. Third, regulation of the fibrotic pathways induced by miRNAs is found in many other tissues in addition to the heart, lung, liver, and kidney. Interestingly, the actions of many drugs on the human body are also induced by miRNAs. It is encouraging that the fibrotic process can be blocked or reversed by targeting specific miRNAs and their signaling pathways, thereby protecting the structures and functions of different organs. CONCLUSIONS: miRNAs not only regulate molecular signaling pathways in fibrosis but also serve as potential targets of novel therapeutic interventions for fibrosing diseases.
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spelling pubmed-50400242016-10-12 Regulatory Mechanisms of the Molecular Pathways in Fibrosis Induced by MicroRNAs Yang, Cui Zheng, Si-Dao Wu, Hong-Jin Chen, Shao-Jun Chin Med J (Engl) Review Article OBJECTIVE: MicroRNAs (miRNAs or miRs) play critical roles in the fibrotic process in different organs. We summarized the latest research progress on the roles and mechanisms of miRNAs in the regulation of the molecular signaling pathways involved in fibrosis. DATA SOURCES: Papers published in English from January 2010 to August 2015 were selected from the PubMed and Web of Science databases using the search terms “microRNA”, “miR”, “transforming growth factor β”, “tgf β”, “mitogen-activated protein kinase”, “mapk”, “integrin”, “p38”, “c-Jun NH(2)-terminal kinase”, “jnk”, “extracellular signal-regulated kinase”, “erk”, and “fibrosis”. STUDY SELECTION: Articles were obtained and reviewed to analyze the regulatory effects of miRNAs on molecular signaling pathways involved in the fibrosis. RESULTS: Recent evidence has shown that miRNAs are involved in regulating fibrosis by targeting different substrates in the molecular processes that drive fibrosis, such as immune cell sensitization, effector cell activation, and extracellular matrix remodeling. Moreover, several important molecular signaling pathways involve in fibrosis, such as the transforming growth factor-beta (TGF-β) pathway, mitogen-activated protein kinase (MAPK) pathways, and the integrin pathway are regulated by miRNAs. Third, regulation of the fibrotic pathways induced by miRNAs is found in many other tissues in addition to the heart, lung, liver, and kidney. Interestingly, the actions of many drugs on the human body are also induced by miRNAs. It is encouraging that the fibrotic process can be blocked or reversed by targeting specific miRNAs and their signaling pathways, thereby protecting the structures and functions of different organs. CONCLUSIONS: miRNAs not only regulate molecular signaling pathways in fibrosis but also serve as potential targets of novel therapeutic interventions for fibrosing diseases. Medknow Publications & Media Pvt Ltd 2016-10-05 /pmc/articles/PMC5040024/ /pubmed/27647197 http://dx.doi.org/10.4103/0366-6999.190677 Text en Copyright: © 2016 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Yang, Cui
Zheng, Si-Dao
Wu, Hong-Jin
Chen, Shao-Jun
Regulatory Mechanisms of the Molecular Pathways in Fibrosis Induced by MicroRNAs
title Regulatory Mechanisms of the Molecular Pathways in Fibrosis Induced by MicroRNAs
title_full Regulatory Mechanisms of the Molecular Pathways in Fibrosis Induced by MicroRNAs
title_fullStr Regulatory Mechanisms of the Molecular Pathways in Fibrosis Induced by MicroRNAs
title_full_unstemmed Regulatory Mechanisms of the Molecular Pathways in Fibrosis Induced by MicroRNAs
title_short Regulatory Mechanisms of the Molecular Pathways in Fibrosis Induced by MicroRNAs
title_sort regulatory mechanisms of the molecular pathways in fibrosis induced by micrornas
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040024/
https://www.ncbi.nlm.nih.gov/pubmed/27647197
http://dx.doi.org/10.4103/0366-6999.190677
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