Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect

This review discusses two distinct, yet related, mechanisms of sodium-glucose cotransporter 2 (SGLT2) inhibition: Calorie restriction mimicry (CRM) and pro-ketogenic effect, which may explain their cardiovascular benefits. We term these adaptive CRM and pro-ketogenic effects of SGLT2 inhibition, the...

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Autores principales: Kalra, Sanjay, Jain, Arpit, Ved, Jignesh, Unnikrishnan, A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040058/
https://www.ncbi.nlm.nih.gov/pubmed/27730088
http://dx.doi.org/10.4103/2230-8210.183826
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author Kalra, Sanjay
Jain, Arpit
Ved, Jignesh
Unnikrishnan, A. G.
author_facet Kalra, Sanjay
Jain, Arpit
Ved, Jignesh
Unnikrishnan, A. G.
author_sort Kalra, Sanjay
collection PubMed
description This review discusses two distinct, yet related, mechanisms of sodium-glucose cotransporter 2 (SGLT2) inhibition: Calorie restriction mimicry (CRM) and pro-ketogenic effect, which may explain their cardiovascular benefits. We term these adaptive CRM and pro-ketogenic effects of SGLT2 inhibition, the Robin Hood hypothesis. In English history, Robin Hood was a “good person,” who stole from the rich and helped the poor. He supported redistribution of resources as he deemed fit for the common good. In a similar fashion, SGLT2 inhibition provides respite to the overloaded glucose metabolism while utilizing lipid stores for energy production.
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spelling pubmed-50400582016-10-11 Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect Kalra, Sanjay Jain, Arpit Ved, Jignesh Unnikrishnan, A. G. Indian J Endocrinol Metab Brief Communication This review discusses two distinct, yet related, mechanisms of sodium-glucose cotransporter 2 (SGLT2) inhibition: Calorie restriction mimicry (CRM) and pro-ketogenic effect, which may explain their cardiovascular benefits. We term these adaptive CRM and pro-ketogenic effects of SGLT2 inhibition, the Robin Hood hypothesis. In English history, Robin Hood was a “good person,” who stole from the rich and helped the poor. He supported redistribution of resources as he deemed fit for the common good. In a similar fashion, SGLT2 inhibition provides respite to the overloaded glucose metabolism while utilizing lipid stores for energy production. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5040058/ /pubmed/27730088 http://dx.doi.org/10.4103/2230-8210.183826 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Brief Communication
Kalra, Sanjay
Jain, Arpit
Ved, Jignesh
Unnikrishnan, A. G.
Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect
title Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect
title_full Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect
title_fullStr Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect
title_full_unstemmed Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect
title_short Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect
title_sort sodium-glucose cotransporter 2 inhibition and health benefits: the robin hood effect
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040058/
https://www.ncbi.nlm.nih.gov/pubmed/27730088
http://dx.doi.org/10.4103/2230-8210.183826
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