Reduced neuronal size and mTOR pathway activity in the Mecp2 A140V Rett syndrome mouse model

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutation in the X-linked MECP2 gene, encoding methyl-CpG-binding protein 2. We have created a mouse model ( Mecp2 A140V “knock-in” mutant) expressing the recurrent human MECP2 A140V mutation linked to an X-linked mental retardation/Rett...

Descripción completa

Detalles Bibliográficos
Autores principales: Rangasamy, Sampathkumar, Olfers, Shannon, Gerald, Brittany, Hilbert, Alex, Svejda, Sean, Narayanan, Vinodh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040159/
https://www.ncbi.nlm.nih.gov/pubmed/27781091
http://dx.doi.org/10.12688/f1000research.8156.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040159/
https://www.ncbi.nlm.nih.gov/pubmed/27781091
http://dx.doi.org/10.12688/f1000research.8156.1

Ejemplares similares