Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD

Pulmonary inflammation and bacterial colonization are central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Defects in macrophage phagocytosis of both bacteria and apoptotic cells contribute to the COPD phenotype. Small molecule inhibitors with anti-inflammatory activity again...

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Detalles Bibliográficos
Autores principales: Bewley, Martin A., Belchamber, Kylie B. R., Chana, Kirandeep K., Budd, Richard C., Donaldson, Gavin, Wedzicha, Jadwiga A., Brightling, Christopher E., Kilty, Iain, Donnelly, Louise E., Barnes, Peter J., Singh, Dave, Whyte, Moira K. B., Dockrell, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040258/
https://www.ncbi.nlm.nih.gov/pubmed/27680884
http://dx.doi.org/10.1371/journal.pone.0163139

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