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Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies
BACKGROUND: Overweight/obesity has been reported to worsen pulmonary function (PF). This study aimed to examine the association between PF and several body composition (BC) measures in two population-based cohorts. METHODS: We performed a cross-sectional analysis of individuals aged 18 and 30 years...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040394/ https://www.ncbi.nlm.nih.gov/pubmed/27682232 http://dx.doi.org/10.1371/journal.pone.0163428 |
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author | de Oliveira, Paula Duarte Wehrmeister, Fernando C. Pérez-Padilla, Rogelio Gonçalves, Helen Assunção, Maria Cecília F. Horta, Bernardo Lessa Gigante, Denise P. Barros, Fernando C. Menezes, Ana Maria Baptista |
author_facet | de Oliveira, Paula Duarte Wehrmeister, Fernando C. Pérez-Padilla, Rogelio Gonçalves, Helen Assunção, Maria Cecília F. Horta, Bernardo Lessa Gigante, Denise P. Barros, Fernando C. Menezes, Ana Maria Baptista |
author_sort | de Oliveira, Paula Duarte |
collection | PubMed |
description | BACKGROUND: Overweight/obesity has been reported to worsen pulmonary function (PF). This study aimed to examine the association between PF and several body composition (BC) measures in two population-based cohorts. METHODS: We performed a cross-sectional analysis of individuals aged 18 and 30 years from two Pelotas Birth Cohorts in southern Brazil. PF was assessed by spirometry. Body measures that were collected included body mass index, waist circumference, skinfold thickness, percentages of total and segmented (trunk, arms and legs) fat mass (FM) and total fat-free mass (FFM). FM and FFM were measured by air-displacement plethysmography (BODPOD) and by dual-energy x-ray absorptiometry (DXA). Associations were verified through linear regressions stratified by sex, and adjusted for weight, height, skin color, and socioeconomic, behavioral, and perinatal variables. RESULTS: A total of 7347 individuals were included in the analyses (3438 and 3909 at 30 and 18 years, respectively). Most BC measures showed a significant positive association between PF and FFM, and a negative association with FM. For each additional percentage point of FM, measured by BOD POD, the forced vital capacity regression coefficient adjusted by height, weight and skin color, at 18 years, was −33 mL (95% CI −38, −29) and −26 mL (95% CI −30, −22), and −30 mL (95% CI −35, −25) and −19 mL (95% CI −23, −14) at 30 years, in men and women, respectively. All the BOD POD regression coefficients for FFM were the same as for the FM coefficients, but in a positive trend (p<0.001 for all associations). CONCLUSIONS: All measures that distinguish FM from FFM (skinfold thickness–FM estimation–BOD POD, total and segmental DXA measures–FM and FFM proportions) showed negative trends in the association of FM with PF for both ages and sexes. On the other hand, FFM showed a positive association with PF. |
format | Online Article Text |
id | pubmed-5040394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50403942016-10-27 Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies de Oliveira, Paula Duarte Wehrmeister, Fernando C. Pérez-Padilla, Rogelio Gonçalves, Helen Assunção, Maria Cecília F. Horta, Bernardo Lessa Gigante, Denise P. Barros, Fernando C. Menezes, Ana Maria Baptista PLoS One Research Article BACKGROUND: Overweight/obesity has been reported to worsen pulmonary function (PF). This study aimed to examine the association between PF and several body composition (BC) measures in two population-based cohorts. METHODS: We performed a cross-sectional analysis of individuals aged 18 and 30 years from two Pelotas Birth Cohorts in southern Brazil. PF was assessed by spirometry. Body measures that were collected included body mass index, waist circumference, skinfold thickness, percentages of total and segmented (trunk, arms and legs) fat mass (FM) and total fat-free mass (FFM). FM and FFM were measured by air-displacement plethysmography (BODPOD) and by dual-energy x-ray absorptiometry (DXA). Associations were verified through linear regressions stratified by sex, and adjusted for weight, height, skin color, and socioeconomic, behavioral, and perinatal variables. RESULTS: A total of 7347 individuals were included in the analyses (3438 and 3909 at 30 and 18 years, respectively). Most BC measures showed a significant positive association between PF and FFM, and a negative association with FM. For each additional percentage point of FM, measured by BOD POD, the forced vital capacity regression coefficient adjusted by height, weight and skin color, at 18 years, was −33 mL (95% CI −38, −29) and −26 mL (95% CI −30, −22), and −30 mL (95% CI −35, −25) and −19 mL (95% CI −23, −14) at 30 years, in men and women, respectively. All the BOD POD regression coefficients for FFM were the same as for the FM coefficients, but in a positive trend (p<0.001 for all associations). CONCLUSIONS: All measures that distinguish FM from FFM (skinfold thickness–FM estimation–BOD POD, total and segmental DXA measures–FM and FFM proportions) showed negative trends in the association of FM with PF for both ages and sexes. On the other hand, FFM showed a positive association with PF. Public Library of Science 2016-09-28 /pmc/articles/PMC5040394/ /pubmed/27682232 http://dx.doi.org/10.1371/journal.pone.0163428 Text en © 2016 Oliveira et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article de Oliveira, Paula Duarte Wehrmeister, Fernando C. Pérez-Padilla, Rogelio Gonçalves, Helen Assunção, Maria Cecília F. Horta, Bernardo Lessa Gigante, Denise P. Barros, Fernando C. Menezes, Ana Maria Baptista Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies |
title | Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies |
title_full | Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies |
title_fullStr | Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies |
title_full_unstemmed | Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies |
title_short | Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies |
title_sort | relationship between body composition and pulmonary function in early adult life: a cross-sectional analysis nested in two birth cohort studies |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040394/ https://www.ncbi.nlm.nih.gov/pubmed/27682232 http://dx.doi.org/10.1371/journal.pone.0163428 |
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