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Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies

BACKGROUND: Overweight/obesity has been reported to worsen pulmonary function (PF). This study aimed to examine the association between PF and several body composition (BC) measures in two population-based cohorts. METHODS: We performed a cross-sectional analysis of individuals aged 18 and 30 years...

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Autores principales: de Oliveira, Paula Duarte, Wehrmeister, Fernando C., Pérez-Padilla, Rogelio, Gonçalves, Helen, Assunção, Maria Cecília F., Horta, Bernardo Lessa, Gigante, Denise P., Barros, Fernando C., Menezes, Ana Maria Baptista
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040394/
https://www.ncbi.nlm.nih.gov/pubmed/27682232
http://dx.doi.org/10.1371/journal.pone.0163428
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author de Oliveira, Paula Duarte
Wehrmeister, Fernando C.
Pérez-Padilla, Rogelio
Gonçalves, Helen
Assunção, Maria Cecília F.
Horta, Bernardo Lessa
Gigante, Denise P.
Barros, Fernando C.
Menezes, Ana Maria Baptista
author_facet de Oliveira, Paula Duarte
Wehrmeister, Fernando C.
Pérez-Padilla, Rogelio
Gonçalves, Helen
Assunção, Maria Cecília F.
Horta, Bernardo Lessa
Gigante, Denise P.
Barros, Fernando C.
Menezes, Ana Maria Baptista
author_sort de Oliveira, Paula Duarte
collection PubMed
description BACKGROUND: Overweight/obesity has been reported to worsen pulmonary function (PF). This study aimed to examine the association between PF and several body composition (BC) measures in two population-based cohorts. METHODS: We performed a cross-sectional analysis of individuals aged 18 and 30 years from two Pelotas Birth Cohorts in southern Brazil. PF was assessed by spirometry. Body measures that were collected included body mass index, waist circumference, skinfold thickness, percentages of total and segmented (trunk, arms and legs) fat mass (FM) and total fat-free mass (FFM). FM and FFM were measured by air-displacement plethysmography (BODPOD) and by dual-energy x-ray absorptiometry (DXA). Associations were verified through linear regressions stratified by sex, and adjusted for weight, height, skin color, and socioeconomic, behavioral, and perinatal variables. RESULTS: A total of 7347 individuals were included in the analyses (3438 and 3909 at 30 and 18 years, respectively). Most BC measures showed a significant positive association between PF and FFM, and a negative association with FM. For each additional percentage point of FM, measured by BOD POD, the forced vital capacity regression coefficient adjusted by height, weight and skin color, at 18 years, was −33 mL (95% CI −38, −29) and −26 mL (95% CI −30, −22), and −30 mL (95% CI −35, −25) and −19 mL (95% CI −23, −14) at 30 years, in men and women, respectively. All the BOD POD regression coefficients for FFM were the same as for the FM coefficients, but in a positive trend (p<0.001 for all associations). CONCLUSIONS: All measures that distinguish FM from FFM (skinfold thickness–FM estimation–BOD POD, total and segmental DXA measures–FM and FFM proportions) showed negative trends in the association of FM with PF for both ages and sexes. On the other hand, FFM showed a positive association with PF.
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spelling pubmed-50403942016-10-27 Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies de Oliveira, Paula Duarte Wehrmeister, Fernando C. Pérez-Padilla, Rogelio Gonçalves, Helen Assunção, Maria Cecília F. Horta, Bernardo Lessa Gigante, Denise P. Barros, Fernando C. Menezes, Ana Maria Baptista PLoS One Research Article BACKGROUND: Overweight/obesity has been reported to worsen pulmonary function (PF). This study aimed to examine the association between PF and several body composition (BC) measures in two population-based cohorts. METHODS: We performed a cross-sectional analysis of individuals aged 18 and 30 years from two Pelotas Birth Cohorts in southern Brazil. PF was assessed by spirometry. Body measures that were collected included body mass index, waist circumference, skinfold thickness, percentages of total and segmented (trunk, arms and legs) fat mass (FM) and total fat-free mass (FFM). FM and FFM were measured by air-displacement plethysmography (BODPOD) and by dual-energy x-ray absorptiometry (DXA). Associations were verified through linear regressions stratified by sex, and adjusted for weight, height, skin color, and socioeconomic, behavioral, and perinatal variables. RESULTS: A total of 7347 individuals were included in the analyses (3438 and 3909 at 30 and 18 years, respectively). Most BC measures showed a significant positive association between PF and FFM, and a negative association with FM. For each additional percentage point of FM, measured by BOD POD, the forced vital capacity regression coefficient adjusted by height, weight and skin color, at 18 years, was −33 mL (95% CI −38, −29) and −26 mL (95% CI −30, −22), and −30 mL (95% CI −35, −25) and −19 mL (95% CI −23, −14) at 30 years, in men and women, respectively. All the BOD POD regression coefficients for FFM were the same as for the FM coefficients, but in a positive trend (p<0.001 for all associations). CONCLUSIONS: All measures that distinguish FM from FFM (skinfold thickness–FM estimation–BOD POD, total and segmental DXA measures–FM and FFM proportions) showed negative trends in the association of FM with PF for both ages and sexes. On the other hand, FFM showed a positive association with PF. Public Library of Science 2016-09-28 /pmc/articles/PMC5040394/ /pubmed/27682232 http://dx.doi.org/10.1371/journal.pone.0163428 Text en © 2016 Oliveira et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
de Oliveira, Paula Duarte
Wehrmeister, Fernando C.
Pérez-Padilla, Rogelio
Gonçalves, Helen
Assunção, Maria Cecília F.
Horta, Bernardo Lessa
Gigante, Denise P.
Barros, Fernando C.
Menezes, Ana Maria Baptista
Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies
title Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies
title_full Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies
title_fullStr Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies
title_full_unstemmed Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies
title_short Relationship between Body Composition and Pulmonary Function in Early Adult Life: A Cross-Sectional Analysis Nested in Two Birth Cohort Studies
title_sort relationship between body composition and pulmonary function in early adult life: a cross-sectional analysis nested in two birth cohort studies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040394/
https://www.ncbi.nlm.nih.gov/pubmed/27682232
http://dx.doi.org/10.1371/journal.pone.0163428
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