An Amphotericin B Derivative Equally Potent to Amphotericin B and with Increased Safety

Amphotericin B is the most potent antimycotic known to date. However due to its large collateral toxicity, its use, although long standing, had been limited. Many attempts have been made to produce derivatives with reduced collateral damage. The molecular mechanism of polyene has also been closely s...

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Detalles Bibliográficos
Autores principales: Antillón, Armando, de Vries, Alexander H., Espinosa-Caballero, Marcel, Falcón-González, José Marcos, Flores Romero, David, González–Damián, Javier, Jiménez-Montejo, Fabiola Eloísa, León-Buitimea, Angel, López-Ortiz, Manuel, Magaña, Ricardo, Marrink, Siewert J., Morales-Nava, Rosmarbel, Periole, Xavier, Reyes-Esparza, Jorge, Rodríguez Lozada, Josué, Santiago-Angelino, Tania Minerva, Vargas González, María Cristina, Regla, Ignacio, Carrillo-Tripp, Mauricio, Fernández-Zertuche, Mario, Rodríguez-Fragoso, Lourdes, Ortega-Blake, Iván
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040443/
https://www.ncbi.nlm.nih.gov/pubmed/27683101
http://dx.doi.org/10.1371/journal.pone.0162171

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