Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL

Phosphoinositides (PIs) control fundamental cell processes, and inherited defects of PI kinases or phosphatases cause severe human diseases including Lowe syndrome due to mutations in OCRL that encodes a PI(4,5)P(2) 5-phosphatase. Here we unveil a lysosomal response to the arrival of autophagosomal...

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Detalles Bibliográficos
Autores principales: De Leo, Maria Giovanna, Staiano, Leopoldo, Vicinanza, Mariella, Luciani, Alessandro, Carissimo, Annamaria, Mutarelli, Margherita, Di Campli, Antonella, Polishchuk, Elena, Di Tullio, Giuseppe, Morra, Valentina, Levtchenko, Elena, Oltrabella, Francesca, Starborg, Tobias, Santoro, Michele, Di Bernardo, Diego, Devuyst, Olivier, Lowe, Martin, Medina, Diego L., Ballabio, Andrea, De Matteis, Maria Antonietta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040511/
https://www.ncbi.nlm.nih.gov/pubmed/27398910
http://dx.doi.org/10.1038/ncb3386

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