Progranulin Levels in Plasma and Cerebrospinal Fluid in Granulin Mutation Carriers

BACKGROUND: Pathogenic mutations in the granulin gene (GRN) are causative in 5-10% of patients with frontotemporal dementia (FTD), mostly leading to reduced progranulin protein (PGRN) levels. Upcoming therapeutic trials focus on enhancing PGRN levels. METHODS: Fluctuations in plasma PGRN (n = 41) an...

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Detalles Bibliográficos
Autores principales: Meeter, Lieke H.H., Patzke, Holger, Loewen, Gordon, Dopper, Elise G.P., Pijnenburg, Yolande A.L., van Minkelen, Rick, van Swieten, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040889/
https://www.ncbi.nlm.nih.gov/pubmed/27703466
http://dx.doi.org/10.1159/000447738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040889/
https://www.ncbi.nlm.nih.gov/pubmed/27703466
http://dx.doi.org/10.1159/000447738

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