Aberrant Wnt Signaling in Leukemia

The Wnt signaling pathway is essential in the development and homeostasis of blood and immune cells, but its exact role is still controversial and is the subject of intense research. The malignant counterpart of normal hematopoietic cells, leukemic (stem) cells, have hijacked the Wnt pathway for the...

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Detalles Bibliográficos
Autores principales: Staal, Frank J. T., Famili, Farbod, Garcia Perez, Laura, Pike-Overzet, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040980/
https://www.ncbi.nlm.nih.gov/pubmed/27571104
http://dx.doi.org/10.3390/cancers8090078
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author Staal, Frank J. T.
Famili, Farbod
Garcia Perez, Laura
Pike-Overzet, Karin
author_facet Staal, Frank J. T.
Famili, Farbod
Garcia Perez, Laura
Pike-Overzet, Karin
author_sort Staal, Frank J. T.
collection PubMed
description The Wnt signaling pathway is essential in the development and homeostasis of blood and immune cells, but its exact role is still controversial and is the subject of intense research. The malignant counterpart of normal hematopoietic cells, leukemic (stem) cells, have hijacked the Wnt pathway for their self-renewal and proliferation. Here we review the multiple ways dysregulated Wnt signaling can contribute to leukemogenesis, both cell autonomously as well as by changes in the microenvironment.
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spelling pubmed-50409802016-10-05 Aberrant Wnt Signaling in Leukemia Staal, Frank J. T. Famili, Farbod Garcia Perez, Laura Pike-Overzet, Karin Cancers (Basel) Review The Wnt signaling pathway is essential in the development and homeostasis of blood and immune cells, but its exact role is still controversial and is the subject of intense research. The malignant counterpart of normal hematopoietic cells, leukemic (stem) cells, have hijacked the Wnt pathway for their self-renewal and proliferation. Here we review the multiple ways dysregulated Wnt signaling can contribute to leukemogenesis, both cell autonomously as well as by changes in the microenvironment. MDPI 2016-08-26 /pmc/articles/PMC5040980/ /pubmed/27571104 http://dx.doi.org/10.3390/cancers8090078 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Staal, Frank J. T.
Famili, Farbod
Garcia Perez, Laura
Pike-Overzet, Karin
Aberrant Wnt Signaling in Leukemia
title Aberrant Wnt Signaling in Leukemia
title_full Aberrant Wnt Signaling in Leukemia
title_fullStr Aberrant Wnt Signaling in Leukemia
title_full_unstemmed Aberrant Wnt Signaling in Leukemia
title_short Aberrant Wnt Signaling in Leukemia
title_sort aberrant wnt signaling in leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040980/
https://www.ncbi.nlm.nih.gov/pubmed/27571104
http://dx.doi.org/10.3390/cancers8090078
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