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Synchrotron-Based in Situ Characterization of the Scaffold Mass Loss from Erosion Degradation

The mass loss behavior of degradable tissue scaffolds is critical to their lifespan and other degradation-related properties including mechanical strength and mass transport characteristics. This paper presents a novel method based on synchrotron imaging to characterize the scaffold mass loss from e...

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Detalles Bibliográficos
Autores principales: Bawolin, Nahshon K., Chen, Xiongbaio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040990/
https://www.ncbi.nlm.nih.gov/pubmed/27399789
http://dx.doi.org/10.3390/jfb7030017
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author Bawolin, Nahshon K.
Chen, Xiongbaio
author_facet Bawolin, Nahshon K.
Chen, Xiongbaio
author_sort Bawolin, Nahshon K.
collection PubMed
description The mass loss behavior of degradable tissue scaffolds is critical to their lifespan and other degradation-related properties including mechanical strength and mass transport characteristics. This paper presents a novel method based on synchrotron imaging to characterize the scaffold mass loss from erosion degradation in situ, or without the need of extracting scaffolds once implanted. Specifically, the surface-eroding degradation of scaffolds in a degrading medium was monitored in situ by synchrotron-based imaging; and the time-dependent geometry of scaffolds captured by images was then employed to estimate their mass loss with time, based on the mathematical model that was adopted from the literature of surface erosion with the experimentally-identified model parameters. Acceptable agreement between experimental results and model predictions was observed for scaffolds in a cylindrical shape, made from poly(lactic-co-glycolic) acid (PLGA) and polycaprolactone (PCL). This study illustrates that geometry evaluation by synchrotron-based imaging is an effective means to in situ characterize the scaffold mass loss as well as possibly other degradation-related properties.
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spelling pubmed-50409902016-10-05 Synchrotron-Based in Situ Characterization of the Scaffold Mass Loss from Erosion Degradation Bawolin, Nahshon K. Chen, Xiongbaio J Funct Biomater Article The mass loss behavior of degradable tissue scaffolds is critical to their lifespan and other degradation-related properties including mechanical strength and mass transport characteristics. This paper presents a novel method based on synchrotron imaging to characterize the scaffold mass loss from erosion degradation in situ, or without the need of extracting scaffolds once implanted. Specifically, the surface-eroding degradation of scaffolds in a degrading medium was monitored in situ by synchrotron-based imaging; and the time-dependent geometry of scaffolds captured by images was then employed to estimate their mass loss with time, based on the mathematical model that was adopted from the literature of surface erosion with the experimentally-identified model parameters. Acceptable agreement between experimental results and model predictions was observed for scaffolds in a cylindrical shape, made from poly(lactic-co-glycolic) acid (PLGA) and polycaprolactone (PCL). This study illustrates that geometry evaluation by synchrotron-based imaging is an effective means to in situ characterize the scaffold mass loss as well as possibly other degradation-related properties. MDPI 2016-07-05 /pmc/articles/PMC5040990/ /pubmed/27399789 http://dx.doi.org/10.3390/jfb7030017 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bawolin, Nahshon K.
Chen, Xiongbaio
Synchrotron-Based in Situ Characterization of the Scaffold Mass Loss from Erosion Degradation
title Synchrotron-Based in Situ Characterization of the Scaffold Mass Loss from Erosion Degradation
title_full Synchrotron-Based in Situ Characterization of the Scaffold Mass Loss from Erosion Degradation
title_fullStr Synchrotron-Based in Situ Characterization of the Scaffold Mass Loss from Erosion Degradation
title_full_unstemmed Synchrotron-Based in Situ Characterization of the Scaffold Mass Loss from Erosion Degradation
title_short Synchrotron-Based in Situ Characterization of the Scaffold Mass Loss from Erosion Degradation
title_sort synchrotron-based in situ characterization of the scaffold mass loss from erosion degradation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040990/
https://www.ncbi.nlm.nih.gov/pubmed/27399789
http://dx.doi.org/10.3390/jfb7030017
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