Cargando…

pH-Responsive PLGA Nanoparticle for Controlled Payload Delivery of Diclofenac Sodium

Poly(lactic-co-glycolic acid) (PLGA) based nanoparticles have gained increasing attention in delivery applications due to their capability for controlled drug release characteristics, biocompatibility, and tunable mechanical, as well as degradation, properties. However, thorough study is always requ...

Descripción completa

Detalles Bibliográficos
Autores principales: Khanal, Shalil, Adhikari, Udhab, Rijal, Nava P., Bhattarai, Shanta R., Sankar, Jagannathan, Bhattarai, Narayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040994/
https://www.ncbi.nlm.nih.gov/pubmed/27490577
http://dx.doi.org/10.3390/jfb7030021
_version_ 1782456320926941184
author Khanal, Shalil
Adhikari, Udhab
Rijal, Nava P.
Bhattarai, Shanta R.
Sankar, Jagannathan
Bhattarai, Narayan
author_facet Khanal, Shalil
Adhikari, Udhab
Rijal, Nava P.
Bhattarai, Shanta R.
Sankar, Jagannathan
Bhattarai, Narayan
author_sort Khanal, Shalil
collection PubMed
description Poly(lactic-co-glycolic acid) (PLGA) based nanoparticles have gained increasing attention in delivery applications due to their capability for controlled drug release characteristics, biocompatibility, and tunable mechanical, as well as degradation, properties. However, thorough study is always required while evaluating potential toxicity of the particles from dose dumping, inconsistent release and drug-polymer interactions. In this research, we developed PLGA nanoparticles modified by chitosan (CS), a cationic and pH responsive polysaccharide that bears repetitive amine groups in its backbone. We used a model drug, diclofenac sodium (DS), a nonsteroidal anti-inflammatory drug (NSAID), to study the drug loading and release characteristics. PLGA nanoparticles were synthesized by double-emulsion solvent evaporation technique. The nanoparticles were evaluated based on their particle size, surface charge, entrapment efficacy, and effect of pH in drug release profile. About 390–420 nm of average diameters and uniform morphology of the particles were confirmed by scanning electron microscope (SEM) imaging and dynamic light scattering (DLS) measurement. Chitosan coating over PLGA surface was confirmed by FTIR and DLS. Drug entrapment efficacy was up to 52%. Chitosan coated PLGA showed a pH responsive drug release in in vitro. The release was about 45% more at pH 5.5 than at pH 7.4. The results of our study indicated the development of chitosan coating over PLGA nanoparticle for pH dependent controlled release DS drug for therapeutic applications.
format Online
Article
Text
id pubmed-5040994
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-50409942016-10-05 pH-Responsive PLGA Nanoparticle for Controlled Payload Delivery of Diclofenac Sodium Khanal, Shalil Adhikari, Udhab Rijal, Nava P. Bhattarai, Shanta R. Sankar, Jagannathan Bhattarai, Narayan J Funct Biomater Article Poly(lactic-co-glycolic acid) (PLGA) based nanoparticles have gained increasing attention in delivery applications due to their capability for controlled drug release characteristics, biocompatibility, and tunable mechanical, as well as degradation, properties. However, thorough study is always required while evaluating potential toxicity of the particles from dose dumping, inconsistent release and drug-polymer interactions. In this research, we developed PLGA nanoparticles modified by chitosan (CS), a cationic and pH responsive polysaccharide that bears repetitive amine groups in its backbone. We used a model drug, diclofenac sodium (DS), a nonsteroidal anti-inflammatory drug (NSAID), to study the drug loading and release characteristics. PLGA nanoparticles were synthesized by double-emulsion solvent evaporation technique. The nanoparticles were evaluated based on their particle size, surface charge, entrapment efficacy, and effect of pH in drug release profile. About 390–420 nm of average diameters and uniform morphology of the particles were confirmed by scanning electron microscope (SEM) imaging and dynamic light scattering (DLS) measurement. Chitosan coating over PLGA surface was confirmed by FTIR and DLS. Drug entrapment efficacy was up to 52%. Chitosan coated PLGA showed a pH responsive drug release in in vitro. The release was about 45% more at pH 5.5 than at pH 7.4. The results of our study indicated the development of chitosan coating over PLGA nanoparticle for pH dependent controlled release DS drug for therapeutic applications. MDPI 2016-08-02 /pmc/articles/PMC5040994/ /pubmed/27490577 http://dx.doi.org/10.3390/jfb7030021 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khanal, Shalil
Adhikari, Udhab
Rijal, Nava P.
Bhattarai, Shanta R.
Sankar, Jagannathan
Bhattarai, Narayan
pH-Responsive PLGA Nanoparticle for Controlled Payload Delivery of Diclofenac Sodium
title pH-Responsive PLGA Nanoparticle for Controlled Payload Delivery of Diclofenac Sodium
title_full pH-Responsive PLGA Nanoparticle for Controlled Payload Delivery of Diclofenac Sodium
title_fullStr pH-Responsive PLGA Nanoparticle for Controlled Payload Delivery of Diclofenac Sodium
title_full_unstemmed pH-Responsive PLGA Nanoparticle for Controlled Payload Delivery of Diclofenac Sodium
title_short pH-Responsive PLGA Nanoparticle for Controlled Payload Delivery of Diclofenac Sodium
title_sort ph-responsive plga nanoparticle for controlled payload delivery of diclofenac sodium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040994/
https://www.ncbi.nlm.nih.gov/pubmed/27490577
http://dx.doi.org/10.3390/jfb7030021
work_keys_str_mv AT khanalshalil phresponsiveplgananoparticleforcontrolledpayloaddeliveryofdiclofenacsodium
AT adhikariudhab phresponsiveplgananoparticleforcontrolledpayloaddeliveryofdiclofenacsodium
AT rijalnavap phresponsiveplgananoparticleforcontrolledpayloaddeliveryofdiclofenacsodium
AT bhattaraishantar phresponsiveplgananoparticleforcontrolledpayloaddeliveryofdiclofenacsodium
AT sankarjagannathan phresponsiveplgananoparticleforcontrolledpayloaddeliveryofdiclofenacsodium
AT bhattarainarayan phresponsiveplgananoparticleforcontrolledpayloaddeliveryofdiclofenacsodium