Metabolic profile and safety of piperlongumine

Piperlongumine (PPL), a natural plant product, has been extensively studied in cancer treatment going up on clinical trials. Since the first report related to its use on cancer research (in 2011) around 80 papers have been published in less than 10 years, but a gap still remaining. There are no meta...

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Autores principales: de Lima Moreira, Fernanda, Habenschus, Maísa D., Barth, Thiago, Marques, Lucas M. M., Pilon, Alan Cesar, da Silva Bolzani, Vanderlan, Vessecchi, Ricardo, Lopes, Norberto P., de Oliveira, Anderson R. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041077/
https://www.ncbi.nlm.nih.gov/pubmed/27681015
http://dx.doi.org/10.1038/srep33646
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author de Lima Moreira, Fernanda
Habenschus, Maísa D.
Barth, Thiago
Marques, Lucas M. M.
Pilon, Alan Cesar
da Silva Bolzani, Vanderlan
Vessecchi, Ricardo
Lopes, Norberto P.
de Oliveira, Anderson R. M.
author_facet de Lima Moreira, Fernanda
Habenschus, Maísa D.
Barth, Thiago
Marques, Lucas M. M.
Pilon, Alan Cesar
da Silva Bolzani, Vanderlan
Vessecchi, Ricardo
Lopes, Norberto P.
de Oliveira, Anderson R. M.
author_sort de Lima Moreira, Fernanda
collection PubMed
description Piperlongumine (PPL), a natural plant product, has been extensively studied in cancer treatment going up on clinical trials. Since the first report related to its use on cancer research (in 2011) around 80 papers have been published in less than 10 years, but a gap still remaining. There are no metabolism studies of PPL in human organism. For the lack of a better view, here, the CYP450 in vitro oxidation of PPL was described for the first time. In addition, the enzymatic kinetic data, the predicted in vivo parameters, the produced metabolites, the phenotyping study and possible piperlongumine-drug interactions in vivo is presented.
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spelling pubmed-50410772016-09-30 Metabolic profile and safety of piperlongumine de Lima Moreira, Fernanda Habenschus, Maísa D. Barth, Thiago Marques, Lucas M. M. Pilon, Alan Cesar da Silva Bolzani, Vanderlan Vessecchi, Ricardo Lopes, Norberto P. de Oliveira, Anderson R. M. Sci Rep Article Piperlongumine (PPL), a natural plant product, has been extensively studied in cancer treatment going up on clinical trials. Since the first report related to its use on cancer research (in 2011) around 80 papers have been published in less than 10 years, but a gap still remaining. There are no metabolism studies of PPL in human organism. For the lack of a better view, here, the CYP450 in vitro oxidation of PPL was described for the first time. In addition, the enzymatic kinetic data, the predicted in vivo parameters, the produced metabolites, the phenotyping study and possible piperlongumine-drug interactions in vivo is presented. Nature Publishing Group 2016-09-29 /pmc/articles/PMC5041077/ /pubmed/27681015 http://dx.doi.org/10.1038/srep33646 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
de Lima Moreira, Fernanda
Habenschus, Maísa D.
Barth, Thiago
Marques, Lucas M. M.
Pilon, Alan Cesar
da Silva Bolzani, Vanderlan
Vessecchi, Ricardo
Lopes, Norberto P.
de Oliveira, Anderson R. M.
Metabolic profile and safety of piperlongumine
title Metabolic profile and safety of piperlongumine
title_full Metabolic profile and safety of piperlongumine
title_fullStr Metabolic profile and safety of piperlongumine
title_full_unstemmed Metabolic profile and safety of piperlongumine
title_short Metabolic profile and safety of piperlongumine
title_sort metabolic profile and safety of piperlongumine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041077/
https://www.ncbi.nlm.nih.gov/pubmed/27681015
http://dx.doi.org/10.1038/srep33646
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