Rescue of Early bace-1 and Global DNA Demethylation by S-Adenosylmethionine Reduces Amyloid Pathology and Improves Cognition in an Alzheimer’s Model

General DNA hypomethylation is associated with Alzheimer’s disease (AD), but it is unclear when DNA hypomethylation starts or plays a role in AD pathology or whether DNA re-methylation would rescue early amyloid-related cognitive impairments. In an APP transgenic mouse model of AD-like amyloid patho...

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Detalles Bibliográficos
Autores principales: Do Carmo, Sonia, Hanzel, Cecilia E., Jacobs, Marie L., Machnes, Ziv, Iulita, M. Florencia, Yang, Jingyun, Yu, Lei, Ducatenzeiler, Adriana, Danik, Marc, Breuillaud, Lionel S., Bennett, David A., Szyf, Moshe, Cuello, A. Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041108/
https://www.ncbi.nlm.nih.gov/pubmed/27681803
http://dx.doi.org/10.1038/srep34051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041108/
https://www.ncbi.nlm.nih.gov/pubmed/27681803
http://dx.doi.org/10.1038/srep34051

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