Cargando…

Presumed LRP1-targeting transport peptide delivers β-secretase inhibitor to neurons in vitro with limited efficiency

Interfering with the activity of β-secretase to reduce the production of Aβ peptides is a conceivable therapeutic strategy for Alzheimer’s disease. However, the development of efficient yet safe inhibitors is hampered by secondary effects, usually linked to the indiscriminate inhibition of other sub...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Jong Ah, Casalini, Tommaso, Brambilla, Davide, Leroux, Jean-Christophe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041153/ https://www.ncbi.nlm.nih.gov/pubmed/27682851 http://dx.doi.org/10.1038/srep34297

Ejemplares similares

A lipid boundary separates APP and secretases and limits amyloid β-peptide generation
por: Kaether, Christoph, et al.
Publicado: (2004)

LRP1 Downregulates the Alzheimer’s β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking1,2,3
por: Tanokashira, Daisuke, et al.
Publicado: (2015)

Topographic distinction in long-term value signals between presumed dopamine neurons and presumed striatal projection neurons in behaving monkeys
por: Enomoto, Kazuki, et al.
Publicado: (2020)

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels
por: Schedin-Weiss, Sophia, et al.
Publicado: (2017)

LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease
por: Spuch, Carlos, et al.
Publicado: (2012)

What is presumed when we presume consent?
por: Pierscionek, Barbara K
Publicado: (2008)

Substrate interaction inhibits γ-secretase production of amyloid-β peptides
por: Zhao, Jing, et al.
Publicado: (2020)

Monoamine oxidase B is associated with γ-secretase in cultured neurons and in brain
por: Weiss, Sophia Schedin, et al.
Publicado: (2013)

Proteomics in neurons and animals: substrates and therapeutic potential of alpha-and beta-secretase
por: Lichtenthaler, Stefan
Publicado: (2013)

Effects of the γ-secretase inhibitor semagacestat on hippocampal neuronal network oscillation
por: Hajós, Mihály, et al.
Publicado: (2013)

Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis
por: Benitez Amaro, Aleyda, et al.
Publicado: (2021)

Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA
por: Yamada, Mariko, et al.
Publicado: (2019)

LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
por: Ren, Qian, et al.
Publicado: (2021)

Presumed osteosarcoma
por: Kettritz, Ralph, et al.
Publicado: (2013)

Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
por: Steiner, Harald, et al.
Publicado: (2018)

Stalling secretase assembly
por: Williams, Ruth
Publicado: (2007)

LRP1 is a neuronal receptor for α-synuclein uptake and spread
por: Chen, Kai, et al.
Publicado: (2022)

Presumed consent: licenses and limits inferred from the case of geriatric hip fractures
por: Bernstein, Joseph, et al.
Publicado: (2017)

Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors
por: Kegel, Kimberly B, et al.
Publicado: (2010)

Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse
por: Schedin-Weiss, Sophia, et al.
Publicado: (2016)

Neurotrophin receptors, gamma-secretase inhibitors, and neurodegeneration of basal forebrain cholinergic neurons
por: Vilar, Marçal
Publicado: (2021)

3D printing of a wearable personalized oral delivery device: A first-in-human study
por: Liang, Kun, et al.
Publicado: (2018)

Elevated expression of cholesterol transporter LRP-1 is crucially implicated in the pathobiology of glioblastoma
por: N. R., Shruthi, et al.
Publicado: (2022)

Presumed Sertraline-Associated Maculopathy: A Case Series
por: Javidi, Hedayat, et al.
Publicado: (2021)

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site
por: Uemura, Kengo, et al.
Publicado: (2010)

Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors
por: Ran, Yong, et al.
Publicado: (2015)

Presynaptic LRP4 promotes synapse number and function of excitatory CNS neurons
por: Mosca, Timothy J, et al.
Publicado: (2017)

LRP4 LDLα repeats of astrocyte enhance dendrite arborization of the neuron
por: Yan, Min, et al.
Publicado: (2020)

Neuronal LRP4 directs the development, maturation, and cytoskeletal organization of peripheral synapses
por: DePew, Alison T., et al.
Publicado: (2023)

Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease
por: Guix, Francesc X, et al.
Publicado: (2012)

P60TRP interferes with the GPCR/secretase pathway to mediate neuronal survival and synaptogenesis
por: Mishra, Manisha, et al.
Publicado: (2011)

Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons
por: Watanabe, Hirotaka, et al.
Publicado: (2021)

Dissecting Molecular Differences between Wnt Coreceptors LRP5 and LRP6
por: MacDonald, Bryan T., et al.
Publicado: (2011)

Low density lipoprotein receptors LRP-1 and LRP-2 in C. elegans
por: Minor, Paul J, et al.
Publicado: (2019)

Presenilin/γ-Secretase and Inflammation
por: Saura, Carlos A.
Publicado: (2010)

The biological function of β-secretase
por: Haass, Christian
Publicado: (2013)

Repression of Alzheimer's beta-Secretase
por: Liao, Francesca-Fang, et al.
Publicado: (2013)

γ-Secretase in Alzheimer’s disease
por: Hur, Ji-Yeun
Publicado: (2022)

Efficient production of a mature and functional gamma secretase protease
por: Khan, Imran, et al.
Publicado: (2018)

LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State
por: Herr, Uta-Mareike, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bvvgcr56mmrpgsub7c5bha1o7o