Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stress

The nuclear orphan receptor, Nur77 plays important roles in neuroimflammation, apoptosis, and dopaminergic neurodegeneration. We conducted a further mechanistic investigation into the association of Nur77 with cell death. Cytosporone B (Csn-B), an agonist for Nur77, and Nur77 knockdown were adopted...

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Detalles Bibliográficos
Autores principales: Gao, Huimin, Chen, Zhaoyu, Fu, Yongmei, Yang, Xiaoyan, Weng, Ruihui, Wang, Rui, Lu, Jianjun, Pan, Mengqiu, Jin, Kunlin, McElroy, Chris, Tang, Beisha, Xia, Ying, Wang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041156/
https://www.ncbi.nlm.nih.gov/pubmed/27679973
http://dx.doi.org/10.1038/srep34403

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