Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth

Mutations in the p53 tumor-suppressor gene are prevalent in human cancers. The majority of p53 mutations are missense, which can be classified into contact mutations (that directly disrupts the DNA-binding activity of p53) and structural mutations (that disrupts the conformation of p53). Both of the...

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Detalles Bibliográficos
Autores principales: Aggarwal, M, Saxena, R, Sinclair, E, Fu, Y, Jacobs, A, Dyba, M, Wang, X, Cruz, I, Berry, D, Kallakury, B, Mueller, S C, Agostino, S D, Blandino, G, Avantaggiati, M L, Chung, F-L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041190/
https://www.ncbi.nlm.nih.gov/pubmed/27258787
http://dx.doi.org/10.1038/cdd.2016.48

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