IL-27 attenuates airway inflammation in a mouse asthma model via the STAT1 and GADD45γ/p38 MAPK pathways

BACKGROUND: Asthma is prone to Th2-mediated chronic airway inflammation. Interleukin-27 (IL-27) is a member of the IL-12 family that promotes the differentiation of Th1 cells and inhibits Th2 cells. We use human/mouse CD4(+) T cells to see whether IL-27 could inhibit IL-4 production in vitro and the...

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Detalles Bibliográficos
Autores principales: Su, Xiaoqiong, Pan, Jue, Bai, Fengxi, Yuan, Honglei, Dong, Nian, Li, Dandan, Wang, Xiangdong, Chen, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041330/
https://www.ncbi.nlm.nih.gov/pubmed/27687913
http://dx.doi.org/10.1186/s12967-016-1039-x

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