Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning

Attenuation of ribosome biogenesis in suboptimal growth environments is crucial for cellular homeostasis and genetic integrity. Here, we show that shutdown of rRNA synthesis in response to elevated temperature is brought about by mechanisms that target both the RNA polymerase I (Pol I) transcription...

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Detalles Bibliográficos
Autores principales: Zhao, Zhongliang, Dammert, Marcel A., Hoppe, Sven, Bierhoff, Holger, Grummt, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041454/
https://www.ncbi.nlm.nih.gov/pubmed/27257073
http://dx.doi.org/10.1093/nar/gkw496

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