Cargando…

Strand displacement synthesis by yeast DNA polymerase ε

DNA polymerase ε (Pol ε) is a replicative DNA polymerase with an associated 3′–5′ exonuclease activity. Here, we explored the capacity of Pol ε to perform strand displacement synthesis, a process that influences many DNA transactions in vivo. We found that Pol ε is unable to carry out extended stran...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ganai, Rais A., Zhang, Xiao-Ping, Heyer, Wolf-Dietrich, Johansson, Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041465/ https://www.ncbi.nlm.nih.gov/pubmed/27325747 http://dx.doi.org/10.1093/nar/gkw556

Ejemplares similares

Switching between polymerase and exonuclease sites in DNA polymerase ε
por: Ganai, Rais A., et al.
Publicado: (2015)

Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB
por: Plaza-G.A., Ismael, et al.
Publicado: (2023)

Replicative DNA polymerases promote active displacement of SSB proteins during lagging strand synthesis
por: Cerrón, Fernando, et al.
Publicado: (2019)

Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels
por: Barbari, Stephanie R, et al.
Publicado: (2022)

Sulfolobus chromatin proteins modulate strand displacement by DNA polymerase B1
por: Sun, Fei, et al.
Publicado: (2013)

Structural evidence for an essential Fe–S cluster in the catalytic core domain of DNA polymerase ϵ
por: ter Beek, Josy, et al.
Publicado: (2019)

DNA polymerase η contributes to genome-wide lagging strand synthesis
por: Kreisel, Katrin, et al.
Publicado: (2019)

Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant
por: Bulock, Chelsea R, et al.
Publicado: (2020)

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
por: Sabouri, Nasim, et al.
Publicado: (2008)

Saccharomyces cerevisiae DNA polymerase IV overcomes Rad51 inhibition of DNA polymerase δ in Rad52-mediated direct-repeat recombination
por: Cerqueira, Paula G, et al.
Publicado: (2023)

Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles
por: Herzog, Mareike, et al.
Publicado: (2021)

Polymerases ε and ∂ repair dysfunctional telomeres facilitated by salt
por: Ivanova, Iglika G., et al.
Publicado: (2016)

Reconstitution of recombination-associated DNA synthesis with human proteins
por: Sneeden, Jessica L., et al.
Publicado: (2013)

Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing
por: He, Liu, et al.
Publicado: (2023)

Interaction between Escherichia coli DNA polymerase IV and single-stranded DNA-binding protein is required for DNA synthesis on SSB-coated DNA
por: Furukohri, Asako, et al.
Publicado: (2012)

Role of the Polymerase ϵ sub-unit DPB2 in DNA replication, cell cycle regulation and DNA damage response in Arabidopsis
por: Pedroza-Garcia, José Antonio, et al.
Publicado: (2016)

Bacillus subtilis DNA polymerases, PolC and DnaE, are required for both leading and lagging strand synthesis in SPP1 origin-dependent DNA replication
por: Seco, Elena M., et al.
Publicado: (2017)

Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro
por: Talhaoui, Ibtissam, et al.
Publicado: (2016)

DNA polymerase θ-mediated repair of high LET radiation-induced complex DNA double-strand breaks
por: Yi, Geunil, et al.
Publicado: (2023)

DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation
por: Lormand, Justin D., et al.
Publicado: (2013)

Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks
por: Burger, Kaspar, et al.
Publicado: (2019)

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate
por: Ström, Cecilia E., et al.
Publicado: (2011)

Human CTF18-RFC clamp-loader complexed with non-synthesising DNA polymerase ε efficiently loads the PCNA sliding clamp
por: Fujisawa, Ryo, et al.
Publicado: (2017)

Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
por: Schaub, Jeffrey M, et al.
Publicado: (2022)

Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing
por: Paliwal, Shreya, et al.
Publicado: (2014)

The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ
por: Hirota, Kouji, et al.
Publicado: (2015)

Dual roles of yeast Rad51 N-terminal domain in repairing DNA double-strand breaks
por: Woo, Tai-Ting, et al.
Publicado: (2020)

Functional interplay of DnaE polymerase, DnaG primase and DnaC helicase within a ternary complex, and primase to polymerase hand-off during lagging strand DNA replication in Bacillus subtilis
por: Rannou, Olivier, et al.
Publicado: (2013)

Targeting DNA polymerase to DNA double-strand breaks reduces DNA deletion size and increases templated insertions generated by CRISPR/Cas9
por: Yoo, Kyung W, et al.
Publicado: (2022)

Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines
por: Degtyareva, Natalya P., et al.
Publicado: (2013)

Translesion-synthesis DNA polymerases participate in replication of the telomeres in Streptomyces
por: Tsai, Hsiu-Hui, et al.
Publicado: (2012)

In vivo evidence for translesion synthesis by the replicative DNA polymerase δ
por: Hirota, Kouji, et al.
Publicado: (2016)

DSS1 and ssDNA regulate oligomerization of BRCA2
por: Le, Hang Phuong, et al.
Publicado: (2020)

The SWI/SNF ATP-dependent nucleosome remodeler promotes resection initiation at a DNA double-strand break in yeast
por: Wiest, Nathaniel E., et al.
Publicado: (2017)

Structure-dependent bypass of DNA interstrand crosslinks by translesion synthesis polymerases
por: Ho, The Vinh, et al.
Publicado: (2011)

DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein
por: Morin, José A., et al.
Publicado: (2017)

Polynucleotide phosphorylase exonuclease and polymerase activities on single-stranded DNA ends are modulated by RecN, SsbA and RecA proteins
por: Cardenas, Paula P., et al.
Publicado: (2011)

Single-molecule live-cell imaging reveals RecB-dependent function of DNA polymerase IV in double strand break repair
por: Henrikus, Sarah S, et al.
Publicado: (2020)

Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system
por: Zhao, Bailin, et al.
Publicado: (2020)

Site-directed mutagenesis of the χ subunit of DNA polymerase III and single-stranded DNA-binding protein of E. coli reveals key residues for their interaction
por: Naue, Natalie, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_2k8fng8jlc0337tqkokh1m6j90