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Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study
BACKGROUND: The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown. The purpose of the study was to unravel environmental markers associated with T1D. METHODS: Cases were children wit...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041527/ https://www.ncbi.nlm.nih.gov/pubmed/27682602 http://dx.doi.org/10.1186/s12889-016-3690-9 |
| _version_ | 1782456431734161408 |
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| author | Balazard, F. Le Fur, S. Valtat, S. Valleron, A. J. Bougnères, P. Thevenieau, Dominique Chatel, Corinne Fourmy Desailloud, Rachel Bony-Trifunovic, Hélène Ducluzeau, Pierre-Henri Coutant, Régis Caudrelier, Sophie Pambou, Armelle Dubosclard, Emmanuelle Joubert, Florence Jan, Philippe Marcoux, Estelle Bertrand, Anne-Marie Mignot, Brigitte Penformis, Alfred Stuckens, Chantal Piquemal, Régis Barat, Pascal Rigalleau, Vincent Stheneur, Chantal Fournier, Sylviane Kerlan, Véronique Metz, Chantal Fargeot-Espaliat, Anne Reznic, Yves Olivier, Frédérique Gueorguieva, Iva Monier, Arnaud Radet, Catherine Gajdos, Vincent Terral, Daniel Vervel, Christine Bendifallah, Djamel Signor, Candace Ben Dervaux, Daniel Benmahammed, Abdelkader Loeuille, Guy-André Popelard, Françoise Guillou, Agnès Benhamou, Pierre-Yves Khoury, Jamil Brossier, Jean-Pierre Bassil, Joachim Clavel, Sylvaine Le Luyer, Bernard Bougnères, Pierre Labay, Françoise Guemas, Isabelle Weill, Jacques Cappoen, Jean-Pierre Nadalon, Sylvie Lienhardt-Roussie, Anne Paoli, Anne Kerouedan, Claudie Yollin, Edwige Nicolino, Marc Simonin, Gilbert Cohen, Jacques Atlan, Catherine Tamboura, Agnès Dubourg, Hervé Pignol, Marie-Laure Talon, Philippe Jellimann, Stéphanie Chaillous, Lucy Baron, Sabine Bortoluzzi, Marie-Noëlle Baechler, Elisabeth Salet, Randa Zelinsky-Gurung, Ariane Dallavale, Fabienne Larger, Etienne Laloi-Michelin, Marie Gautier, Jean-François Guérin, Bénédicte Oilleau, Laure Pantalone, Laetitia Lukas, Céline Guilhem, Isabelle De Kerdanet, Marc Wielickzo, Marie-Claire Priou-Guesdon, Mélanie Richard, Odile Kurtz, François Laisney, Norbert Ancelle, Déborah Parlier, Guilhem Boniface, Catherine Bockel, Dominique Paris Dufillot, Denis Razafimahefa, Berthe Gourdy, Pierre Lecomte, Pierre Pepin-Donat, Myriam Combes-Moukhovsky, Marie-Emmanuelle Zymmermann, Brigitte Raoulx, Marina Dumont, Anne Gourdin et Catherine |
| author_facet | Balazard, F. Le Fur, S. Valtat, S. Valleron, A. J. Bougnères, P. Thevenieau, Dominique Chatel, Corinne Fourmy Desailloud, Rachel Bony-Trifunovic, Hélène Ducluzeau, Pierre-Henri Coutant, Régis Caudrelier, Sophie Pambou, Armelle Dubosclard, Emmanuelle Joubert, Florence Jan, Philippe Marcoux, Estelle Bertrand, Anne-Marie Mignot, Brigitte Penformis, Alfred Stuckens, Chantal Piquemal, Régis Barat, Pascal Rigalleau, Vincent Stheneur, Chantal Fournier, Sylviane Kerlan, Véronique Metz, Chantal Fargeot-Espaliat, Anne Reznic, Yves Olivier, Frédérique Gueorguieva, Iva Monier, Arnaud Radet, Catherine Gajdos, Vincent Terral, Daniel Vervel, Christine Bendifallah, Djamel Signor, Candace Ben Dervaux, Daniel Benmahammed, Abdelkader Loeuille, Guy-André Popelard, Françoise Guillou, Agnès Benhamou, Pierre-Yves Khoury, Jamil Brossier, Jean-Pierre Bassil, Joachim Clavel, Sylvaine Le Luyer, Bernard Bougnères, Pierre Labay, Françoise Guemas, Isabelle Weill, Jacques Cappoen, Jean-Pierre Nadalon, Sylvie Lienhardt-Roussie, Anne Paoli, Anne Kerouedan, Claudie Yollin, Edwige Nicolino, Marc Simonin, Gilbert Cohen, Jacques Atlan, Catherine Tamboura, Agnès Dubourg, Hervé Pignol, Marie-Laure Talon, Philippe Jellimann, Stéphanie Chaillous, Lucy Baron, Sabine Bortoluzzi, Marie-Noëlle Baechler, Elisabeth Salet, Randa Zelinsky-Gurung, Ariane Dallavale, Fabienne Larger, Etienne Laloi-Michelin, Marie Gautier, Jean-François Guérin, Bénédicte Oilleau, Laure Pantalone, Laetitia Lukas, Céline Guilhem, Isabelle De Kerdanet, Marc Wielickzo, Marie-Claire Priou-Guesdon, Mélanie Richard, Odile Kurtz, François Laisney, Norbert Ancelle, Déborah Parlier, Guilhem Boniface, Catherine Bockel, Dominique Paris Dufillot, Denis Razafimahefa, Berthe Gourdy, Pierre Lecomte, Pierre Pepin-Donat, Myriam Combes-Moukhovsky, Marie-Emmanuelle Zymmermann, Brigitte Raoulx, Marina Dumont, Anne Gourdin et Catherine |
| author_sort | Balazard, F. |
| collection | PubMed |
| description | BACKGROUND: The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown. The purpose of the study was to unravel environmental markers associated with T1D. METHODS: Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends of the patients. Parents were asked to fill a 845-item questionnaire investigating the child’s environment before diagnosis. The analysis took into account the matching between cases and controls. A second analysis used propensity score methods. RESULTS: We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnut cocoa spread consumption, wasp and bee stings with T1D, consumption of vegetables from a farm and death of a pet by old age. CONCLUSIONS: The found statistical association of new environmental markers with T1D calls for replication in other cohorts and investigation of new environmental areas. TRIAL REGISTRATION: Clinical-Trial.gov NCT02212522. Registered August 6, 2014. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12889-016-3690-9) contains supplementary material, which is available to authorized users. |
| format | Online Article Text |
| id | pubmed-5041527 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-50415272016-10-05 Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study Balazard, F. Le Fur, S. Valtat, S. Valleron, A. J. Bougnères, P. Thevenieau, Dominique Chatel, Corinne Fourmy Desailloud, Rachel Bony-Trifunovic, Hélène Ducluzeau, Pierre-Henri Coutant, Régis Caudrelier, Sophie Pambou, Armelle Dubosclard, Emmanuelle Joubert, Florence Jan, Philippe Marcoux, Estelle Bertrand, Anne-Marie Mignot, Brigitte Penformis, Alfred Stuckens, Chantal Piquemal, Régis Barat, Pascal Rigalleau, Vincent Stheneur, Chantal Fournier, Sylviane Kerlan, Véronique Metz, Chantal Fargeot-Espaliat, Anne Reznic, Yves Olivier, Frédérique Gueorguieva, Iva Monier, Arnaud Radet, Catherine Gajdos, Vincent Terral, Daniel Vervel, Christine Bendifallah, Djamel Signor, Candace Ben Dervaux, Daniel Benmahammed, Abdelkader Loeuille, Guy-André Popelard, Françoise Guillou, Agnès Benhamou, Pierre-Yves Khoury, Jamil Brossier, Jean-Pierre Bassil, Joachim Clavel, Sylvaine Le Luyer, Bernard Bougnères, Pierre Labay, Françoise Guemas, Isabelle Weill, Jacques Cappoen, Jean-Pierre Nadalon, Sylvie Lienhardt-Roussie, Anne Paoli, Anne Kerouedan, Claudie Yollin, Edwige Nicolino, Marc Simonin, Gilbert Cohen, Jacques Atlan, Catherine Tamboura, Agnès Dubourg, Hervé Pignol, Marie-Laure Talon, Philippe Jellimann, Stéphanie Chaillous, Lucy Baron, Sabine Bortoluzzi, Marie-Noëlle Baechler, Elisabeth Salet, Randa Zelinsky-Gurung, Ariane Dallavale, Fabienne Larger, Etienne Laloi-Michelin, Marie Gautier, Jean-François Guérin, Bénédicte Oilleau, Laure Pantalone, Laetitia Lukas, Céline Guilhem, Isabelle De Kerdanet, Marc Wielickzo, Marie-Claire Priou-Guesdon, Mélanie Richard, Odile Kurtz, François Laisney, Norbert Ancelle, Déborah Parlier, Guilhem Boniface, Catherine Bockel, Dominique Paris Dufillot, Denis Razafimahefa, Berthe Gourdy, Pierre Lecomte, Pierre Pepin-Donat, Myriam Combes-Moukhovsky, Marie-Emmanuelle Zymmermann, Brigitte Raoulx, Marina Dumont, Anne Gourdin et Catherine BMC Public Health Research Article BACKGROUND: The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown. The purpose of the study was to unravel environmental markers associated with T1D. METHODS: Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends of the patients. Parents were asked to fill a 845-item questionnaire investigating the child’s environment before diagnosis. The analysis took into account the matching between cases and controls. A second analysis used propensity score methods. RESULTS: We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnut cocoa spread consumption, wasp and bee stings with T1D, consumption of vegetables from a farm and death of a pet by old age. CONCLUSIONS: The found statistical association of new environmental markers with T1D calls for replication in other cohorts and investigation of new environmental areas. TRIAL REGISTRATION: Clinical-Trial.gov NCT02212522. Registered August 6, 2014. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12889-016-3690-9) contains supplementary material, which is available to authorized users. BioMed Central 2016-09-29 /pmc/articles/PMC5041527/ /pubmed/27682602 http://dx.doi.org/10.1186/s12889-016-3690-9 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Research Article Balazard, F. Le Fur, S. Valtat, S. Valleron, A. J. Bougnères, P. Thevenieau, Dominique Chatel, Corinne Fourmy Desailloud, Rachel Bony-Trifunovic, Hélène Ducluzeau, Pierre-Henri Coutant, Régis Caudrelier, Sophie Pambou, Armelle Dubosclard, Emmanuelle Joubert, Florence Jan, Philippe Marcoux, Estelle Bertrand, Anne-Marie Mignot, Brigitte Penformis, Alfred Stuckens, Chantal Piquemal, Régis Barat, Pascal Rigalleau, Vincent Stheneur, Chantal Fournier, Sylviane Kerlan, Véronique Metz, Chantal Fargeot-Espaliat, Anne Reznic, Yves Olivier, Frédérique Gueorguieva, Iva Monier, Arnaud Radet, Catherine Gajdos, Vincent Terral, Daniel Vervel, Christine Bendifallah, Djamel Signor, Candace Ben Dervaux, Daniel Benmahammed, Abdelkader Loeuille, Guy-André Popelard, Françoise Guillou, Agnès Benhamou, Pierre-Yves Khoury, Jamil Brossier, Jean-Pierre Bassil, Joachim Clavel, Sylvaine Le Luyer, Bernard Bougnères, Pierre Labay, Françoise Guemas, Isabelle Weill, Jacques Cappoen, Jean-Pierre Nadalon, Sylvie Lienhardt-Roussie, Anne Paoli, Anne Kerouedan, Claudie Yollin, Edwige Nicolino, Marc Simonin, Gilbert Cohen, Jacques Atlan, Catherine Tamboura, Agnès Dubourg, Hervé Pignol, Marie-Laure Talon, Philippe Jellimann, Stéphanie Chaillous, Lucy Baron, Sabine Bortoluzzi, Marie-Noëlle Baechler, Elisabeth Salet, Randa Zelinsky-Gurung, Ariane Dallavale, Fabienne Larger, Etienne Laloi-Michelin, Marie Gautier, Jean-François Guérin, Bénédicte Oilleau, Laure Pantalone, Laetitia Lukas, Céline Guilhem, Isabelle De Kerdanet, Marc Wielickzo, Marie-Claire Priou-Guesdon, Mélanie Richard, Odile Kurtz, François Laisney, Norbert Ancelle, Déborah Parlier, Guilhem Boniface, Catherine Bockel, Dominique Paris Dufillot, Denis Razafimahefa, Berthe Gourdy, Pierre Lecomte, Pierre Pepin-Donat, Myriam Combes-Moukhovsky, Marie-Emmanuelle Zymmermann, Brigitte Raoulx, Marina Dumont, Anne Gourdin et Catherine Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study |
| title | Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study |
| title_full | Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study |
| title_fullStr | Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study |
| title_full_unstemmed | Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study |
| title_short | Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study |
| title_sort | association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041527/ https://www.ncbi.nlm.nih.gov/pubmed/27682602 http://dx.doi.org/10.1186/s12889-016-3690-9 |
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associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT gautierjeanfrancois associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT guerinbenedicte associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT oilleaulaure associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT pantalonelaetitia associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT lukasceline associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT guilhemisabelle associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT dekerdanetmarc associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT wielickzomarieclaire associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT priouguesdonmelanie associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT richardodile associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT kurtzfrancois associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT laisneynorbert associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT ancelledeborah associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT parlierguilhem associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT bonifacecatherine associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT bockeldominiqueparis associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT dufillotdenis associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT razafimahefaberthe associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT gourdypierre associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT lecomtepierre associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT pepindonatmyriam associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT combesmoukhovskymarieemmanuelle associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT zymmermannbrigitte associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT raoulxmarina associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT dumontannegourdinetcatherine associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy |