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Immunomodulatory effects of nicotine on interleukin 1β activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism

BACKGROUND: The cholinergic anti-inflammatory pathway (CAP) primarily functions through acetylcholine (ACh)-alpha7 nicotinic acetylcholine receptor (α7nAChR) interaction on macrophages to control peripheral inflammation. Interestingly, ACh can also bind α7nAChRs on microglia resulting in neuroprotec...

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Detalles Bibliográficos
Autores principales:	Revathikumar, Priya, Bergqvist, Filip, Gopalakrishnan, Srividya, Korotkova, Marina, Jakobsson, Per-Johan, Lampa, Jon, Le Maître, Erwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041575/ https://www.ncbi.nlm.nih.gov/pubmed/27681882 http://dx.doi.org/10.1186/s12974-016-0725-1

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