A new immunohistochemistry prognostic score (IPS) for recurrence and survival in resected pancreatic neuroendocrine tumors (PanNET)

Pancreatic neuroendocrine tumor (PanNET) is a neoplastic entity in which few prognostic factors are well-known. Here, we aimed to evaluate the prognostic significance of N-myc downstream-regulated gen-1 (NDRG-1), O6-methylguanine DNA methyltransferase (MGMT) and Pleckstrin homology-like domain famil...

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Detalles Bibliográficos
Autores principales: Viúdez, Antonio, Carvalho, Filipe L.F., Maleki, Zahra, Zahurak, Marianna, Laheru, Daniel, Stark, Alejandro, Azad, Nilofer Z., Wolfgang, Christopher L., Baylin, Stephen, Herman, James G., De Jesus-Acosta, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Papers: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041882/
https://www.ncbi.nlm.nih.gov/pubmed/26894863
http://dx.doi.org/10.18632/oncotarget.7436
Descripción
Sumario:Pancreatic neuroendocrine tumor (PanNET) is a neoplastic entity in which few prognostic factors are well-known. Here, we aimed to evaluate the prognostic significance of N-myc downstream-regulated gen-1 (NDRG-1), O6-methylguanine DNA methyltransferase (MGMT) and Pleckstrin homology-like domain family A member 3 (PHLDA-3) by immunohistochemistry (IHC) and methylation analysis in 92 patients with resected PanNET and follow-up longer than 24 months. In multivariate analyses, ki-67 and our immunohistochemistry prognostic score (IPS-based on MGMT, NDRG-1 and PHLDA-3 IHC expression) were independent prognostic factors for disease-free-survival (DFS), while age and IPS were independent prognostic factors for overall survival (OS). Our IPS could be a useful prognostic biomarker for recurrence and survival in patients following resection for PanNET.

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