Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization

Squamous cell carcinomas of the lung and of the head and neck district share strong association with smoking habits and are characterized by smoke-related genetic alterations. Driver mutations have been identified in small percentage of lung squamous cell carcinoma. In parallel, squamous head and ne...

Descripción completa

Detalles Bibliográficos
Autores principales: Polo, Valentina, Pasello, Giulia, Frega, Stefano, Favaretto, Adolfo, Koussis, Haralabos, Conte, Pierfranco, Bonanno, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041888/
https://www.ncbi.nlm.nih.gov/pubmed/26933818
http://dx.doi.org/10.18632/oncotarget.7732
_version_ 1782456500814348288
author Polo, Valentina
Pasello, Giulia
Frega, Stefano
Favaretto, Adolfo
Koussis, Haralabos
Conte, Pierfranco
Bonanno, Laura
author_facet Polo, Valentina
Pasello, Giulia
Frega, Stefano
Favaretto, Adolfo
Koussis, Haralabos
Conte, Pierfranco
Bonanno, Laura
author_sort Polo, Valentina
collection PubMed
description Squamous cell carcinomas of the lung and of the head and neck district share strong association with smoking habits and are characterized by smoke-related genetic alterations. Driver mutations have been identified in small percentage of lung squamous cell carcinoma. In parallel, squamous head and neck tumors are classified according to the HPV positivity, thus identifying two different clinical and molecular subgroups of disease. This review depicts different molecular portraits and potential clinical application in the field of targeted therapy, immunotherapy and chemotherapy personalization.
format Online
Article
Text
id pubmed-5041888
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-50418882016-10-10 Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization Polo, Valentina Pasello, Giulia Frega, Stefano Favaretto, Adolfo Koussis, Haralabos Conte, Pierfranco Bonanno, Laura Oncotarget Review Squamous cell carcinomas of the lung and of the head and neck district share strong association with smoking habits and are characterized by smoke-related genetic alterations. Driver mutations have been identified in small percentage of lung squamous cell carcinoma. In parallel, squamous head and neck tumors are classified according to the HPV positivity, thus identifying two different clinical and molecular subgroups of disease. This review depicts different molecular portraits and potential clinical application in the field of targeted therapy, immunotherapy and chemotherapy personalization. Impact Journals LLC 2016-02-25 /pmc/articles/PMC5041888/ /pubmed/26933818 http://dx.doi.org/10.18632/oncotarget.7732 Text en Copyright: © 2016 Polo et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Polo, Valentina
Pasello, Giulia
Frega, Stefano
Favaretto, Adolfo
Koussis, Haralabos
Conte, Pierfranco
Bonanno, Laura
Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization
title Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization
title_full Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization
title_fullStr Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization
title_full_unstemmed Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization
title_short Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization
title_sort squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041888/
https://www.ncbi.nlm.nih.gov/pubmed/26933818
http://dx.doi.org/10.18632/oncotarget.7732
work_keys_str_mv AT polovalentina squamouscellcarcinomasofthelungandoftheheadandnecknewinsightsonmolecularcharacterization
AT pasellogiulia squamouscellcarcinomasofthelungandoftheheadandnecknewinsightsonmolecularcharacterization
AT fregastefano squamouscellcarcinomasofthelungandoftheheadandnecknewinsightsonmolecularcharacterization
AT favarettoadolfo squamouscellcarcinomasofthelungandoftheheadandnecknewinsightsonmolecularcharacterization
AT koussisharalabos squamouscellcarcinomasofthelungandoftheheadandnecknewinsightsonmolecularcharacterization
AT contepierfranco squamouscellcarcinomasofthelungandoftheheadandnecknewinsightsonmolecularcharacterization
AT bonannolaura squamouscellcarcinomasofthelungandoftheheadandnecknewinsightsonmolecularcharacterization

Ejemplares similares