Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation

The Warburg effect, which reflects cancer cells' preference for aerobic glycolysis over glucose oxidation, contributes to tumor growth, progression and therapy resistance. The restraint on pyruvate flux into mitochondrial oxidative metabolism in cancer cells is in part attributed to the inhibit...

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Detalles Bibliográficos
Autores principales: Jin, Yue, Cai, Qingsong, Shenoy, Anitha K., Lim, Sangbin, Zhang, Ying, Charles, Steve, Tarrash, Miriam, Fu, Xueqi, Kamarajugadda, Sushama, Trevino, Jose G., Tan, Ming, Lu, Jianrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041892/
https://www.ncbi.nlm.nih.gov/pubmed/26848621
http://dx.doi.org/10.18632/oncotarget.7159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041892/
https://www.ncbi.nlm.nih.gov/pubmed/26848621
http://dx.doi.org/10.18632/oncotarget.7159

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