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Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer

BACKGROUND: Genetic intratumoral heterogeneity (ITH) hinders biomarker development in metastatic clear cell renal cancer (mccRCC). Epigenetic relative to genetic ITH or the presence of consistent epigenetic changes following targeted therapy in mccRCC have not been evaluated. The aim of this study w...

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Detalles Bibliográficos
Autores principales:	Stewart, Grant D., Powles, Thomas, Van Neste, Christophe, Meynert, Alison, O'Mahony, Fiach, Laird, Alexander, Deforce, Dieter, Van Nieuwerburgh, Filip, Trooskens, Geert, Van Criekinge, Wim, De Meyer, Tim, Harrison, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041900/ https://www.ncbi.nlm.nih.gov/pubmed/27029034 http://dx.doi.org/10.18632/oncotarget.8308

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