Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma

Alternatively spliced Tissue Factor (asTF) is a secreted form of Tissue Factor (TF), the trigger of blood coagulation whose expression levels are heightened in several forms of solid cancer, including pancreatic ductal adenocarcinoma (PDAC). asTF binds to β1 integrins on PDAC cells, whereby it promo...

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Detalles Bibliográficos
Autores principales: Unruh, Dusten, Ünlü, Betül, Lewis, Clayton S., Qi, Xiaoyang, Chu, Zhengtao, Sturm, Robert, Keil, Ryan, Ahmad, Syed A., Sovershaev, Timofey, Adam, Mariette, Van Dreden, Patrick, Woodhams, Barry J., Ramchandani, Divya, Weber, Georg F., Rak, Janusz W., Wolberg, Alisa S., Mackman, Nigel, Versteeg, Henri H., Bogdanov, Vladimir Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041902/
https://www.ncbi.nlm.nih.gov/pubmed/26967388
http://dx.doi.org/10.18632/oncotarget.7955

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