Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death

The tumor suppressor Spred2 (Sprouty-related EVH1 domain-2) induces cell death in a variety of cancers. However, the underlying mechanism remains to be elucidated. Here we show that Spred2 induces caspase-independent but autophagy-dependent cell death in human cervical carcinoma HeLa and lung cancer...

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Detalles Bibliográficos
Autores principales: Jiang, Ke, Liu, Min, Lin, Guibin, Mao, Beibei, Cheng, Wei, Liu, Han, Gal, Jozsef, Zhu, Haining, Yuan, Zengqiang, Deng, Wuguo, Liu, Quentin, Gong, Peng, Bi, Xiaolin, Meng, Songshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041934/
https://www.ncbi.nlm.nih.gov/pubmed/27028858
http://dx.doi.org/10.18632/oncotarget.8357

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