Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1

Curcumin is potentially therapeutic for malignant diseases. The mechanisms of this effect might involve a combination of antioxidant, immunomodulatory, proapoptotic, and antiangiogenic activities. However, the exact mechanisms are not fully understood. In the present study, we provided evidences tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Guo-Qing, Chai, Ke-Qun, Zhu, Xiu-Ming, Jiang, Hua, Wang, Xiao, Xue, Qian, Zheng, Ai-Hong, Zhou, Hong-Ying, Chen, Yun, Chen, Xiao-Chen, Xiao, Jian-Yong, Ying, Xu-Hua, Wang, Fu-Wei, Rui, Tao, Liao, Yi-Ji, Xie, Dan, Lu, Li-Qin, Huang, Dong-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041997/
https://www.ncbi.nlm.nih.gov/pubmed/27049834
http://dx.doi.org/10.18632/oncotarget.8532
Descripción
Sumario:Curcumin is potentially therapeutic for malignant diseases. The mechanisms of this effect might involve a combination of antioxidant, immunomodulatory, proapoptotic, and antiangiogenic activities. However, the exact mechanisms are not fully understood. In the present study, we provided evidences that curcumin suppressed the expression of enhancer of zeste homolog 2 (EZH2) in lung cancer cells both transcriptionally and post-transcriptionally. Curcumin inhibited the expression of EZH2 through microRNA (miR)-let 7c and miR-101. Curcumin decreased the expression of NOTCH1 through the inhibition of EZH2. There was a reciprocal regulation between EZH2 and NOTCH1 in lung cancer cells. These observations suggest that curcumin inhibits lung cancer growth and metastasis at least partly through the inhibition of EZH2 and NOTCH1.

Ejemplares similares