Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles

B-Raf represents a critical physiological regulator of the Ras/RAF/MEK/ERK-pathway and a pharmacological target of growing clinical relevance, in particular in oncology. To understand how B-Raf itself is regulated, we combined mass spectrometry with genetic approaches to map its interactome in MCF-1...

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Detalles Bibliográficos
Autores principales: Eisenhardt, Anja E., Sprenger, Adrian, Röring, Michael, Herr, Ricarda, Weinberg, Florian, Köhler, Martin, Braun, Sandra, Orth, Joachim, Diedrich, Britta, Lanner, Ulrike, Tscherwinski, Natalja, Schuster, Simon, Dumaz, Nicolas, Schmidt, Enrico, Baumeister, Ralf, Schlosser, Andreas, Dengjel, Jörn, Brummer, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042004/
https://www.ncbi.nlm.nih.gov/pubmed/27034005
http://dx.doi.org/10.18632/oncotarget.8427

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