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Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis
To examine the relationship between cytotoxic T lymphocyte antigen-4 (CTLA-4) expression and esophageal carcinoma prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded primary tumor specimens from 158 patients with esophageal cancer. CTLA-4 was detected in the cytoplas...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042006/ https://www.ncbi.nlm.nih.gov/pubmed/27050369 http://dx.doi.org/10.18632/oncotarget.8476 |
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author | Zhang, Xiao-Fei Pan, Ke Weng, De-Sheng Chen, Chang-Long Wang, Qi-Jing Zhao, Jing-Jing Pan, Qiu-Zhong Liu, Qing Jiang, Shan-Shan Li, Yong-Qiang Zhang, Hong-Xia Xia, Jian-Chuan |
author_facet | Zhang, Xiao-Fei Pan, Ke Weng, De-Sheng Chen, Chang-Long Wang, Qi-Jing Zhao, Jing-Jing Pan, Qiu-Zhong Liu, Qing Jiang, Shan-Shan Li, Yong-Qiang Zhang, Hong-Xia Xia, Jian-Chuan |
author_sort | Zhang, Xiao-Fei |
collection | PubMed |
description | To examine the relationship between cytotoxic T lymphocyte antigen-4 (CTLA-4) expression and esophageal carcinoma prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded primary tumor specimens from 158 patients with esophageal cancer. CTLA-4 was detected in the cytoplasm and cell membranes of esophageal cancer cells and in interstitial lymphocytes. In univariate analyses (log-rank), higher interstitial CTLA-4(+) lymphocyte density and higher tumor CTLA-4 expression were associated with shorter overall survival (OS). After controlling for age and clinical stage, multivariate analysis (Cox) found that tumor CTLA-4 expression was an independent predictor of shorter OS (HR 2.016, P = 0.004). These results indicate that CTLA-4 expression in the tumor environment (both lymphocytes and tumor cells) is associated with poorer prognosis. In addition, CTLA-4 profiles may be useful for predicting the benefits and toxicity of CTLA-4 blockade in patients with esophageal carcinoma. |
format | Online Article Text |
id | pubmed-5042006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-50420062016-10-10 Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis Zhang, Xiao-Fei Pan, Ke Weng, De-Sheng Chen, Chang-Long Wang, Qi-Jing Zhao, Jing-Jing Pan, Qiu-Zhong Liu, Qing Jiang, Shan-Shan Li, Yong-Qiang Zhang, Hong-Xia Xia, Jian-Chuan Oncotarget Research Paper To examine the relationship between cytotoxic T lymphocyte antigen-4 (CTLA-4) expression and esophageal carcinoma prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded primary tumor specimens from 158 patients with esophageal cancer. CTLA-4 was detected in the cytoplasm and cell membranes of esophageal cancer cells and in interstitial lymphocytes. In univariate analyses (log-rank), higher interstitial CTLA-4(+) lymphocyte density and higher tumor CTLA-4 expression were associated with shorter overall survival (OS). After controlling for age and clinical stage, multivariate analysis (Cox) found that tumor CTLA-4 expression was an independent predictor of shorter OS (HR 2.016, P = 0.004). These results indicate that CTLA-4 expression in the tumor environment (both lymphocytes and tumor cells) is associated with poorer prognosis. In addition, CTLA-4 profiles may be useful for predicting the benefits and toxicity of CTLA-4 blockade in patients with esophageal carcinoma. Impact Journals LLC 2016-03-30 /pmc/articles/PMC5042006/ /pubmed/27050369 http://dx.doi.org/10.18632/oncotarget.8476 Text en Copyright: © 2016 Zhang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Zhang, Xiao-Fei Pan, Ke Weng, De-Sheng Chen, Chang-Long Wang, Qi-Jing Zhao, Jing-Jing Pan, Qiu-Zhong Liu, Qing Jiang, Shan-Shan Li, Yong-Qiang Zhang, Hong-Xia Xia, Jian-Chuan Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis |
title | Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis |
title_full | Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis |
title_fullStr | Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis |
title_full_unstemmed | Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis |
title_short | Cytotoxic T lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis |
title_sort | cytotoxic t lymphocyte antigen-4 expression in esophageal carcinoma: implications for prognosis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042006/ https://www.ncbi.nlm.nih.gov/pubmed/27050369 http://dx.doi.org/10.18632/oncotarget.8476 |
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