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Unveiling (−)‐Englerin A as a Modulator of L‐Type Calcium Channels
The voltage‐dependent L‐type Ca(2+)channel was identified as a macromolecular target for (−)‐englerin A. This finding was reached by using an unprecedented ligand‐based prediction platform and the natural product piperlongumine as a pharmacophore probe. (−)‐Englerin A features high substructure diss...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042069/ https://www.ncbi.nlm.nih.gov/pubmed/27391219 http://dx.doi.org/10.1002/anie.201604336 |