Switching of the positive feedback for RAS activation by a concerted function of SOS membrane association domains

Son of sevenless (SOS) is a guanine nucleotide exchange factor that regulates cell behavior by activating the small GTPase RAS. Recent in vitro studies have suggested that an interaction between SOS and the GTP-bound active form of RAS generates a positive feedback loop that propagates RAS activatio...

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Detalles Bibliográficos
Autores principales: Nakamura, Yuki, Hibino, Kayo, Yanagida, Toshio, Sako, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society of Japan (BSJ) 2016
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042160/
https://www.ncbi.nlm.nih.gov/pubmed/27924253
http://dx.doi.org/10.2142/biophysico.13.0_1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042160/
https://www.ncbi.nlm.nih.gov/pubmed/27924253
http://dx.doi.org/10.2142/biophysico.13.0_1

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