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Dynamic profile analysis to characterize dynamics-driven allosteric sites in enzymes
We examine the dynamic features of non-trivial allosteric binding sites to elucidate potential drug binding sites. These allosteric sites were previously found to be allosteric after determination of the protein-drug co-crystal structure. After comprehensive search in the Protein Data Bank, we ident...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society of Japan (BSJ)
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042162/ https://www.ncbi.nlm.nih.gov/pubmed/27924265 http://dx.doi.org/10.2142/biophysico.13.0_117 |