Importance of consensus region of multiple-ligand templates in a virtual screening method

We discuss methods and ideas of virtual screening (VS) for drug discovery by examining the performance of VS-APPLE, a recently developed VS method, which extensively utilizes the tendency of single binding pockets to bind diversely different ligands, i.e. promiscuity of binding pockets. In VS-APPLE,...

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Detalles Bibliográficos
Autores principales: Okuno, Tatsuya, Kato, Koya, Minami, Shintaro, Terada, Tomoki P., Sasai, Masaki, Chikenji, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society of Japan (BSJ) 2016
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042167/
https://www.ncbi.nlm.nih.gov/pubmed/27924269
http://dx.doi.org/10.2142/biophysico.13.0_149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042167/
https://www.ncbi.nlm.nih.gov/pubmed/27924269
http://dx.doi.org/10.2142/biophysico.13.0_149

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