Cargando…

Effects of substrate conformational strain on binding kinetics of catalytic antibodies

We analyzed the correlation between the conformational strain and the binding kinetics in antigen-antibody interactions. The catalytic antibodies 6D9, 9C10, and 7C8 catalyze the hydrolysis of a nonbioactive chloramphenicol monoester derivative to generate a bioactive chloramphenicol. The crystal str...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oda, Masayuki, Tsumuraya, Takeshi, Fujii, Ikuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society of Japan (BSJ) 2016
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042168/ https://www.ncbi.nlm.nih.gov/pubmed/27924267 http://dx.doi.org/10.2142/biophysico.13.0_135

Ejemplares similares

Conformation-controlled binding kinetics of antibodies
por: Galanti, Marta, et al.
Publicado: (2016)

Investigation on substrate specificity and catalytic activity of serine protease neuropsin
por: Lintuluoto, Masami, et al.
Publicado: (2022)

SARS-CoV-2 spike protein binding selectively accelerates substrate-specific catalytic activity of ACE2
por: Kiseleva, Anna A, et al.
Publicado: (2021)

Substrate-binding loop interactions with pseudouridine trigger conformational changes that promote catalytic efficiency of pseudouridine kinase PUKI
por: Kim, Sang-Hoon, et al.
Publicado: (2022)

DNA-binding function of c-Myb R2R3 around thermal denaturation temperature
por: Kawasaki, Maki, et al.
Publicado: (2021)

Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations
por: Wu, Hong, et al.
Publicado: (2013)

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR
por: Csanády, László, et al.
Publicado: (2013)

Chalcogen bond-guided conformational isomerization enables catalytic dynamic kinetic resolution of sulfoxides
por: Liu, Jianjian, et al.
Publicado: (2022)

Structural and functional properties of Grb2 SH2 dimer in CD28 binding
por: Hosoe, Yuhi, et al.
Publicado: (2019)

Chemical Modification of Phage‐Displayed Helix‐Loop‐Helix Peptides to Construct Kinase‐Focused Libraries
por: Fujiwara, Daisuke, et al.
Publicado: (2021)

DNA sequencing using polymerase substrate-binding kinetics
por: Previte, Michael John Robert, et al.
Publicado: (2015)

Rationally Designed Synthetic Haptens to Generate Anti-Ciguatoxin Monoclonal Antibodies, and Development of a Practical Sandwich ELISA to Detect Ciguatoxins
por: Tsumuraya, Takeshi, et al.
Publicado: (2019)

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding
por: Amaral, M., et al.
Publicado: (2017)

Relationship between conformation shift and disease related variation sites in ATP-binding cassette transporter proteins
por: Sakamoto, Mika, et al.
Publicado: (2019)

Role of Repeated Conformational Transitions in Substrate Binding of Adenylate Kinase
por: Lu, Jiajun, et al.
Publicado: (2022)

Biomolecular conformational changes and ligand binding: from kinetics to thermodynamics
por: Wang, Yong, et al.
Publicado: (2017)

Conformational shift in the closed state of GroEL induced by ATP-binding triggers a transition to the open state
por: Suzuki, Yuka, et al.
Publicado: (2016)

Rice BRITTLE CULM 5 (BRITTLE NODE) is Involved in Secondary Cell Wall Formation in the Sclerenchyma Tissue of Nodes
por: Aohara, Tsutomu, et al.
Publicado: (2009)

Conformational dynamics of the human serotonin transporter during substrate and drug binding
por: Möller, Ingvar R., et al.
Publicado: (2019)

Conformational States and Kinetics of the Calcium Binding Domain of NADPH Oxidase 5
por: Wei, Chin-Chuan, et al.
Publicado: (2010)

Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB
por: Wang, Beibei, et al.
Publicado: (2015)

Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication
por: Umehara, Kohei, et al.
Publicado: (2018)

ADAMTS13 conformation and immunoprofiles in Japanese patients with immune-mediated thrombotic thrombocytopenic purpura
por: Sakai, Kazuya, et al.
Publicado: (2022)

Quantitative Correlation of Conformational Binding Enthalpy with Substrate Specificity of Serine Proteases
por: Waldner, Birgit J., et al.
Publicado: (2015)

Arrested Substrate Binding Resolves Catalytic Intermediates in Higher‐Plant Water Oxidation
por: Zahariou, Georgia, et al.
Publicado: (2020)

Computational Insights into Allosteric Conformational Modulation of P-Glycoprotein by Substrate and Inhibitor Binding
por: Xing, Juan, et al.
Publicado: (2020)

Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3
por: Heggelund, Julie Elisabeth, et al.
Publicado: (2023)

Conformations of the apo-, substrate-bound and phosphate-bound ATP-binding domain of the Cu(II) ATPase CopB illustrate coupling of domain movement to the catalytic cycle
por: Jayakanthan, Samuel, et al.
Publicado: (2012)

Investigating the Conformational Stability of Prion Strains through a Kinetic Replication Model
por: Zampieri, Mattia, et al.
Publicado: (2009)

Evanescent scattering imaging of single protein binding kinetics and DNA conformation changes
por: Zhang, Pengfei, et al.
Publicado: (2022)

Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding
por: Miętus, Michał, et al.
Publicado: (2014)

Kinetic Rate Constant Prediction Supports the Conformational Selection Mechanism of Protein Binding
por: Moal, Iain H., et al.
Publicado: (2012)

Promiscuous, non-catalytic, tandem carbohydrate-binding modules modulate the cell-wall structure and development of transgenic tobacco (Nicotiana tabacum) plants
por: Obembe, Olawole O., et al.
Publicado: (2007)

Group 3 sigma factor gene, sigJ, a key regulator of desiccation tolerance, regulates the synthesis of extracellular polysaccharide in cyanobacterium Anabaena sp. strain PCC 7120
por: Yoshimura, Hidehisa, et al.
Publicado: (2007)

Evidence for a Catalytically and Kinetically Competent Enzyme–Substrate Cross-Linked Intermediate in Catalysis by Lipoyl Synthase
por: Lanz, Nicholas D., et al.
Publicado: (2014)

Antigen binding by conformational selection in near-germline antibodies
por: Blackler, Ryan J., et al.
Publicado: (2022)

Photodynamic Effect of Hypericin on the Conformation and Catalytic Activity of Hemoglobin
por: Zhao, Jing, et al.
Publicado: (2008)

Adaptive landscape flattening allows the design of both enzyme: Substrate binding and catalytic power
por: Opuu, Vaitea, et al.
Publicado: (2020)

Catalytic kinetics: chemistry and engineering
por: Murzin, Dmitry Yu, et al.
Publicado: (2016)

Nanopore Detector based analysis of single-molecule conformational kinetics and binding interactions
por: Winters-Hilt, Stephen
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_s3kb77jhthcccrcjomm2t0eoqg