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Effects of substrate conformational strain on binding kinetics of catalytic antibodies

We analyzed the correlation between the conformational strain and the binding kinetics in antigen-antibody interactions. The catalytic antibodies 6D9, 9C10, and 7C8 catalyze the hydrolysis of a nonbioactive chloramphenicol monoester derivative to generate a bioactive chloramphenicol. The crystal str...

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Detalles Bibliográficos
Autores principales:	Oda, Masayuki, Tsumuraya, Takeshi, Fujii, Ikuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society of Japan (BSJ) 2016
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042168/ https://www.ncbi.nlm.nih.gov/pubmed/27924267 http://dx.doi.org/10.2142/biophysico.13.0_135

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