E2-EPF UCP Possesses E3 Ubiquitin Ligase Activity via Its Cysteine 118 Residue

Here, we show that E2-EPF ubiquitin carrier protein (UCP) elongated E3-independent polyubiquitin chains on the lysine residues of von Hippel-Lindau protein (pVHL) and its own lysine residues both in vitro and in vivo. The initiation of the ubiquitin reaction depended on not only Lys11 linkage but al...

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Detalles Bibliográficos
Autores principales: Lim, Jung Hwa, Shin, Hee Won, Chung, Kyung-Sook, Kim, Nam-Soon, Kim, Ju Hee, Jung, Hong-Ryul, Im, Dong-Soo, Jung, Cho-Rok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042379/
https://www.ncbi.nlm.nih.gov/pubmed/27685940
http://dx.doi.org/10.1371/journal.pone.0163710

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