Cargando…

Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2′-Deoxyuridine in Colorectal Cancer Cell Lines

In colorectal cancer chemotherapy, the current standard of care includes combination therapy with 5-fluorouracil (5-FU) and leucovorin (LV). However, the factors that determine the LV-mediated enhancement of 5-FU antitumor activity are not fully understood. Therefore, we investigated the roles of th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsukihara, Hiroshi, Tsunekuni, Kenta, Takechi, Teiji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042458/ https://www.ncbi.nlm.nih.gov/pubmed/27685866 http://dx.doi.org/10.1371/journal.pone.0163961

Ejemplares similares

Cellular pharmacology of multi- and duplex drugsconsisting of ethynylcytidine and 5-fluoro-2′-deoxyuridine
por: Bijnsdorp, Irene V., et al.
Publicado: (2009)

5‐Chloro‐2,4‐dihydroxypyridine, CDHP, prevents lung metastasis of basal‐like breast cancer cells by reducing nascent adhesion formation
por: Itou, Junji, et al.
Publicado: (2018)

5-fluorouracil and 5-fluoro-2'-deoxyuridine follow different metabolic pathways in the induction of cell lethality in L1210 leukaemia.
por: Roobol, C., et al.
Publicado: (1984)

CD44/CD133-Positive Colorectal Cancer Stem Cells are Sensitive to Trifluridine Exposure
por: Tsunekuni, Kenta, et al.
Publicado: (2019)

Development of modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity
por: Wu, Shao-yu, et al.
Publicado: (2013)

Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, together with bevacizumab, cetuximab, or panitumumab on human colorectal cancer xenografts
por: TSUKIHARA, HIROSHI, et al.
Publicado: (2015)

Enzyme kinetics of deoxyuridine triphosphatase from Western corn rootworm
por: Riera-Ruiz, Carlos, et al.
Publicado: (2023)

MicroRNA profiles involved in trifluridine resistance
por: Tsunekuni, Kenta, et al.
Publicado: (2017)

MicroRNA-351 Regulates Two-Types of Cell Death, Necrosis and Apoptosis, Induced by 5-fluoro-2'-deoxyuridine
por: Sato, Akira, et al.
Publicado: (2016)

Parallel G-quadruplex Structures Increase Cellular Uptake and Cytotoxicity of 5-Fluoro-2′-deoxyuridine Oligomers in 5-Fluorouracil Resistant Cells
por: Clua, Anna, et al.
Publicado: (2021)

DNA triplex formation with 5-dimethylaminopropargyl deoxyuridine
por: Rusling, David A., et al.
Publicado: (2009)

Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase.
por: Patterson, A. V., et al.
Publicado: (1995)

Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells
por: Matsumoto, Yoshihiro, et al.
Publicado: (2015)

Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2′-deoxyuridine-5′-monophosphate on ABCC11 in silico models
por: Honorat, Mylène, et al.
Publicado: (2013)

Synthesis and Enzymatic Incorporation of Modified Deoxyuridine Triphosphates
por: Liu, Erkai, et al.
Publicado: (2015)

Genetic variants in the Folic acid Metabolic Pathway Genes predict outcomes of metastatic Colorectal Cancer patients receiving first-line Chemotherapy
por: Jiang, Lu, et al.
Publicado: (2020)

Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer
por: Kawahara, A, et al.
Publicado: (2009)

The antibodies against 5-bromo-2′-deoxyuridine specifically recognize trifluridine incorporated into DNA
por: Kitao, Hiroyuki, et al.
Publicado: (2016)

Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer
por: Suzuki, Norihiko, et al.
Publicado: (2017)

Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer
por: Suzuki, Norihiko, et al.
Publicado: (2021)

Diesterified Derivatives of 5-Iodo-2′-Deoxyuridine as Cerebral Tumor Tracers
por: Rösler, Thomas W., et al.
Publicado: (2014)

Influence of Hypoxia on Radiosensitization of Cancer Cells by 5-Bromo-2′-deoxyuridine
por: Zdrowowicz, Magdalena, et al.
Publicado: (2022)

3′-O-Acetyl-2′-deoxyuridine
por: Doboszewski, Bogdan, et al.
Publicado: (2010)

Folic acid, one-carbon metabolism & childhood cancer
por: Moulik, Nirmalya Roy, et al.
Publicado: (2017)

Adjusting the neuron to astrocyte ratio with cytostatics in hippocampal cell cultures from postnatal rats: A comparison of cytarabino furanoside (AraC) and 5-fluoro-2’-deoxyuridine (FUdR)
por: Lesslich, Heiko M., et al.
Publicado: (2022)

Monitoring DNA replication in fission yeast by incorporation of 5-ethynyl-2′-deoxyuridine
por: Hua, Hui, et al.
Publicado: (2011)

Crystal structure of 5-(dibenzofuran-4-yl)-2′-deoxyuridine
por: Gayakhe, Vijay, et al.
Publicado: (2017)

Radiosensitization of PC3 Prostate Cancer Cells by 5-Thiocyanato-2′-deoxyuridine
por: Zdrowowicz, Magdalena, et al.
Publicado: (2022)

Nucleic Acid Metabolizing Enzyme Levels Predict Chemotherapy Effects in Advanced and Recurrent Colorectal Cancer
por: Watanabe, Mitsuru, et al.
Publicado: (2022)

Deoxyuridines from the Marine Sponge Associated Actinomycete Streptomyces microflavus
por: Li, Ke, et al.
Publicado: (2011)

Crystallization and crystal-packing studies of Chlorella virus deoxyuridine triphosphatase
por: Homma, Kohei, et al.
Publicado: (2009)

A Deoxyuridine-Based Far-Red Emitting Viscosity Sensor
por: Wang, Mengyuan, et al.
Publicado: (2016)

Synthesis and Photophysical Study of 2′-Deoxyuridines Labeled with Fluorene Derivatives
por: Cho, Hyun Yi, et al.
Publicado: (2012)

The relationship between folic acid and colorectal cancer; a literature review
por: Kherbek, Haidara, et al.
Publicado: (2022)

Synthetic Folic Acid
Publicado: (1946)

Safety of folic acid
por: Field, Martha S., et al.
Publicado: (2017)

5-Fluoroisophthalic acid
por: Mi, Jin-Ling, et al.
Publicado: (2011)

Effect of an implanted Walker tumour on metabolism of folic acid in the rat.
por: Barford, P. A., et al.
Publicado: (1978)

Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis
por: SHIMAMOTO, YUJI, et al.
Publicado: (2016)

In vivo uptake of 131I-5-iodo-2-deoxyuridine by malignant tumours in man.
por: Philip, P. A., et al.
Publicado: (1991)

Cannot write session to /tmp/vufind_sessions/sess_feq8sj5sfj3elt159knktffj1e