Cargando…

Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E(2) Synthase 1 and Ser127 Is Not

INTRODUCTION: Prostaglandins are signaling molecules that regulate different physiological processes, involving allergic and inflammatory responses and cardiovascular control. They are involved in several pathophysiological processes, including inflammation and cancer. The inducible terminal enzyme,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raouf, Joan, Rafique, Nazmi, Goodman, Michael Christopher, Idborg, Helena, Bergqvist, Filip, Armstrong, Richard N., Jakobsson, Per-Johan, Morgenstern, Ralf, Spahiu, Linda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042469/ https://www.ncbi.nlm.nih.gov/pubmed/27684486 http://dx.doi.org/10.1371/journal.pone.0163600

Ejemplares similares

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
por: Pawelzik, Sven-Christian, et al.
Publicado: (2010)

Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth
por: Kock, Anna, et al.
Publicado: (2018)

Microsomal Prostaglandin E Synthase-1 in Rheumatic Diseases
por: Korotkova, Marina, et al.
Publicado: (2011)

Fibronectin receptor of human macrophages recognizes the sequence Arg- Gly-Asp-Ser
Publicado: (1985)

Expression of microsomal prostaglandin E synthase-1 in muscle tissue of patients with idiopathic inflammatory myopathies
por: Korotkova, M, et al.
Publicado: (2005)

Antimetastatic effects of synthetic polypeptides containing repeated structures of the cell adhesive Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) sequences.
por: Saiki, I., et al.
Publicado: (1989)

Poly-α, β-d, l-Aspartyl-Arg-Gly-Asp-Ser-Based Urokinase Nanoparticles for Thrombolysis Therapy
por: Chen, Shuangling, et al.
Publicado: (2023)

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E(2)
por: Sampey, Annaleise V, et al.
Publicado: (2005)

Effects of anti-rheumatic treatments on expression of microsomal prostaglandin E synthase-1 in rheumatoid arthritis synovium
por: Korotkova, M, et al.
Publicado: (2004)

The inhibition of murine lung metastasis by synthetic polypeptides [poly(arg-gly-asp) and poly(tyr-ile-gly-ser-arg)] with a core sequence of cell adhesion molecules.
por: Saiki, I., et al.
Publicado: (1989)

The fibronectin cell attachment sequence Arg-Gly-Asp-Ser promotes focal contact formation during early fibroblast attachment and spreading
Publicado: (1987)

Sulforaphane Inhibits Prostaglandin E2 Synthesis by Suppressing Microsomal Prostaglandin E Synthase 1
por: Zhou, Jiping, et al.
Publicado: (2012)

Upregulation of prostaglandin E(2) by inducible microsomal prostaglandin E synthase-1 in colon cancer
por: Kim, Young Hun, et al.
Publicado: (2022)

Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis
por: Korotkova, M, et al.
Publicado: (2008)

Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue
por: Gheorghe, Karina Roxana, et al.
Publicado: (2012)

Modulation of Enzyme-Catalyzed Synthesis of Prostaglandins by Components Contained in Kidney Microsomal Preparations
por: Bai, Hyoung-Woo, et al.
Publicado: (2021)

An Arg-Gly-Asp sequence within thrombin promotes endothelial cell adhesion
Publicado: (1991)

Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors
Publicado: (1988)

Cyclization of the Urokinase Receptor-Derived Ser-Arg-Ser-Arg-Tyr Peptide Generates a Potent Inhibitor of Trans-Endothelial Migration of Monocytes
por: Yousif, Ali Munaim, et al.
Publicado: (2015)

Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen
por: Revathikumar, Priya, et al.
Publicado: (2018)

Association Between the Asp312Asn, Lys751Gln, and Arg156Arg Polymorphisms in XPD and the Risk of Prostate Cancer
por: Fu, Weijin, et al.
Publicado: (2017)

Correction: Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen
por: Revathikumar, Priya, et al.
Publicado: (2018)

Gly322Asp and Asn127Ser single nucleotide polymorphisms (SNPs) of hMSH2 mismatch repair gene and the risk of triple-negative breast cancer in Polish women
por: Smolarz, Beata, et al.
Publicado: (2014)

Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes
por: Afif, H, et al.
Publicado: (2004)

Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1
por: Cao, Long-Long, et al.
Publicado: (2019)

Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice
por: Gurusamy, Malarvizhi, et al.
Publicado: (2021)

Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice
por: Ulmasov, Barbara, et al.
Publicado: (2016)

Histomorphometry of Ossification in Functionalised Ceramics with Tripeptide Arg-Gly-Asp (RGD): An In Vivo Study
por: Migliorini, Filippo, et al.
Publicado: (2022)

Dead-end complex, lipid interactions and catalytic mechanism of microsomal glutathione transferase 1, an electron crystallography and mutagenesis investigation
por: Kuang, Qie, et al.
Publicado: (2017)

Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E(2) synthesis in vitro and ameliorates experimental periodontitis in vivo
por: Kats, Anna, et al.
Publicado: (2013)

The MKK-Dependent Phosphorylation of p38α Is Augmented by Arginine Methylation on Arg49/Arg149 during Erythroid Differentiation
por: Liu, Mei-Yin, et al.
Publicado: (2020)

Structure of N-Terminal Sequence Asp-Ala-Glu-Phe-Arg-His-Asp-Ser of Aβ-Peptide with Phospholipase A(2) from Venom of Andaman Cobra Sub-Species Naja naja sagittifera at 2.0 Å Resolution
por: Mirza, Zeenat, et al.
Publicado: (2014)

Induction of Mast-Cell Accumulation by Promutoxin, an Arg-49 Phospholipase A(2)
por: Wei, Ji-Fu, et al.
Publicado: (2013)

An Update of Microsomal Prostaglandin E Synthase-1 and PGE(2) Receptors in Cardiovascular Health and Diseases
por: Yang, Guangrui, et al.
Publicado: (2016)

Microsomal Prostaglandin E Synthase-1 Deficiency Exacerbates Pulmonary Fibrosis Induced by Bleomycin in Mice
por: Wei, Bo, et al.
Publicado: (2014)

Synergism between Basic Asp49 and Lys49 Phospholipase A(2) Myotoxins of Viperid Snake Venom In Vitro and In Vivo
por: Mora-Obando, Diana, et al.
Publicado: (2014)

Biosynthesis of prostaglandin 15dPGJ(2) -glutathione and 15dPGJ(2)-cysteine conjugates in macrophages and mast cells via MGST3
por: Steinmetz-Späh, Julia, et al.
Publicado: (2022)

Triflavin, an Arg‐Gly‐Asp‐containing Peptide, Inhibits Tumor Cell‐induced Platelet Aggregation
por: Sheu, Joen R., et al.
Publicado: (1993)

Mutation of a Critical Arginine in Microsomal Prostaglandin E Synthase-1 Shifts the Isomerase Activity to a Reductase Activity That Converts Prostaglandin H(2) into Prostaglandin F(2α)
por: Hammarberg, Tove, et al.
Publicado: (2009)

Molecular Characterization of Lys49 and Asp49 Phospholipases A(2) from Snake Venom and Their Antiviral Activities against Dengue virus
por: Cecilio, Alzira B., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vjlohobklu1n9i4boiabeijgh3