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Agmatine Reduces Lipopolysaccharide-Mediated Oxidant Response via Activating PI3K/Akt Pathway and Up-Regulating Nrf2 and HO-1 Expression in Macrophages
Macrophages are key responders of inflammation and are closely related with oxidative stress. Activated macrophages can enhance oxygen depletion, which causes an overproduction of reactive oxygen species (ROS) and leads to further excessive inflammatory response and tissue damage. Agmatine, an endog...
Autores principales: | Chai, Jianshen, Luo, Li, Hou, Fengyan, Fan, Xia, Yu, Jing, Ma, Wei, Tang, Wangqi, Yang, Xue, Zhu, Junyu, Kang, Wenyuan, Yan, Jun, Liang, Huaping |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042521/ https://www.ncbi.nlm.nih.gov/pubmed/27685463 http://dx.doi.org/10.1371/journal.pone.0163634 |
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