Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene

Osteosarcoma (OS) is the most common primary malignant tumor of bone, showing complex chromosomal rearrangements but with few known consistent changes. Deeper biological understanding is crucial to find new therapies to improve patient survival. We have sequenced the whole exome of two primary tumor...

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Detalles Bibliográficos
Autores principales: Barøy, Tale, Chilamakuri, Chandra S. R., Lorenz, Susanne, Sun, Jinchang, Bruland, Øyvind S., Myklebost, Ola, Meza-Zepeda, Leonardo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042545/
https://www.ncbi.nlm.nih.gov/pubmed/27685995
http://dx.doi.org/10.1371/journal.pone.0163859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042545/
https://www.ncbi.nlm.nih.gov/pubmed/27685995
http://dx.doi.org/10.1371/journal.pone.0163859

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