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Integrins as architects of cell behavior

Integrins are cell surface receptors that bind cells to their physical external environment, linking the extracellular matrix to cell function. They are essential in the biology of all animals. In the late 1980s, we discovered that integrins are required for the ability of breast epithelia to do wha...

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Autor principal: Streuli, Charles H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042575/
https://www.ncbi.nlm.nih.gov/pubmed/27687254
http://dx.doi.org/10.1091/mbc.E15-06-0369
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author Streuli, Charles H.
author_facet Streuli, Charles H.
author_sort Streuli, Charles H.
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description Integrins are cell surface receptors that bind cells to their physical external environment, linking the extracellular matrix to cell function. They are essential in the biology of all animals. In the late 1980s, we discovered that integrins are required for the ability of breast epithelia to do what they are programmed to do, which is to differentiate and make milk. Since then, integrins have been shown to control most other aspects of phenotype: to stay alive, to divide, and to move about. Integrins also provide part of the mechanism that allows cells to form tissues. Here I discuss how we discovered that integrins control mammary gland differentiation and explore the role of integrins as central architects of other aspects of cell behavior.
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spelling pubmed-50425752016-12-16 Integrins as architects of cell behavior Streuli, Charles H. Mol Biol Cell Perspective Integrins are cell surface receptors that bind cells to their physical external environment, linking the extracellular matrix to cell function. They are essential in the biology of all animals. In the late 1980s, we discovered that integrins are required for the ability of breast epithelia to do what they are programmed to do, which is to differentiate and make milk. Since then, integrins have been shown to control most other aspects of phenotype: to stay alive, to divide, and to move about. Integrins also provide part of the mechanism that allows cells to form tissues. Here I discuss how we discovered that integrins control mammary gland differentiation and explore the role of integrins as central architects of other aspects of cell behavior. The American Society for Cell Biology 2016-10-01 /pmc/articles/PMC5042575/ /pubmed/27687254 http://dx.doi.org/10.1091/mbc.E15-06-0369 Text en © 2016 Streuli This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.
spellingShingle Perspective
Streuli, Charles H.
Integrins as architects of cell behavior
title Integrins as architects of cell behavior
title_full Integrins as architects of cell behavior
title_fullStr Integrins as architects of cell behavior
title_full_unstemmed Integrins as architects of cell behavior
title_short Integrins as architects of cell behavior
title_sort integrins as architects of cell behavior
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042575/
https://www.ncbi.nlm.nih.gov/pubmed/27687254
http://dx.doi.org/10.1091/mbc.E15-06-0369
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