Cargando…
Protective Effects of Vasodilatory Βeta-Blockers Carvedilol and Nebivolol against Glycerol Model of Rhabdomyolysis-Induced Acute Renal Failure in Rats
BACKGROUND: Rhabdomyolysis (RM)-induced acute renal failure (ARF) accounts for about 10–40% of all cases of ARF. AIM: The present study investigated the possible protective effect of two nitric oxides (NO)-releasing third generation β-blockers, carvedilol (Carv) and nebivolol (Nebi), against RM-mimi...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Institute of Immunobiology and Human Genetics
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042611/ https://www.ncbi.nlm.nih.gov/pubmed/27703551 http://dx.doi.org/10.3889/oamjms.2016.082 |
_version_ | 1782456623286976512 |
---|---|
author | Atwa, Ahmed Hegazy, Rehab Shaffie, Nermeen Yassin, Neamat Kenawy, Sanaa |
author_facet | Atwa, Ahmed Hegazy, Rehab Shaffie, Nermeen Yassin, Neamat Kenawy, Sanaa |
author_sort | Atwa, Ahmed |
collection | PubMed |
description | BACKGROUND: Rhabdomyolysis (RM)-induced acute renal failure (ARF) accounts for about 10–40% of all cases of ARF. AIM: The present study investigated the possible protective effect of two nitric oxides (NO)-releasing third generation β-blockers, carvedilol (Carv) and nebivolol (Nebi), against RM-mimicking glycerol (Gly)-induced ARF in rats. MATERIAL AND METHODS: After 24 h dehydration, rats received a single dose of 50% Gly (8 ml/kg, im). They were treated with vehicle, Carv (2.5 mg/kg/day, po) or Nebi (10 mg/kg, po) for 3 successive days starting from an hour prior to Gly injection. Evaluation of blood pressure and locomotor activity was performed during the experiment. 72 h following Gly administration, total protein in the urine, serum levels of creatinine, blood urea nitrogen, sodium and potassium as well as the renal contents of malondialdehyde, reduced glutathione and NO were assessed, together with a histopathological examination of renal tissues. RESULTS: Carv and Nebi attenuated Gly-induced renal dysfunction and histopathological alterations. They decreased the Gly-induced oxidative stress and increased renal NO concentration. Restoration of normal blood pressure and improvement of locomotor activity were also observed. CONCLUSION: The results clearly demonstrate protective effects of Carv and Nebi against renal damage involved in RM-induced ARF and suggest a role of their antioxidant and NO-releasing properties. |
format | Online Article Text |
id | pubmed-5042611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Institute of Immunobiology and Human Genetics |
record_format | MEDLINE/PubMed |
spelling | pubmed-50426112016-10-04 Protective Effects of Vasodilatory Βeta-Blockers Carvedilol and Nebivolol against Glycerol Model of Rhabdomyolysis-Induced Acute Renal Failure in Rats Atwa, Ahmed Hegazy, Rehab Shaffie, Nermeen Yassin, Neamat Kenawy, Sanaa Open Access Maced J Med Sci Basic Science BACKGROUND: Rhabdomyolysis (RM)-induced acute renal failure (ARF) accounts for about 10–40% of all cases of ARF. AIM: The present study investigated the possible protective effect of two nitric oxides (NO)-releasing third generation β-blockers, carvedilol (Carv) and nebivolol (Nebi), against RM-mimicking glycerol (Gly)-induced ARF in rats. MATERIAL AND METHODS: After 24 h dehydration, rats received a single dose of 50% Gly (8 ml/kg, im). They were treated with vehicle, Carv (2.5 mg/kg/day, po) or Nebi (10 mg/kg, po) for 3 successive days starting from an hour prior to Gly injection. Evaluation of blood pressure and locomotor activity was performed during the experiment. 72 h following Gly administration, total protein in the urine, serum levels of creatinine, blood urea nitrogen, sodium and potassium as well as the renal contents of malondialdehyde, reduced glutathione and NO were assessed, together with a histopathological examination of renal tissues. RESULTS: Carv and Nebi attenuated Gly-induced renal dysfunction and histopathological alterations. They decreased the Gly-induced oxidative stress and increased renal NO concentration. Restoration of normal blood pressure and improvement of locomotor activity were also observed. CONCLUSION: The results clearly demonstrate protective effects of Carv and Nebi against renal damage involved in RM-induced ARF and suggest a role of their antioxidant and NO-releasing properties. Institute of Immunobiology and Human Genetics 2016-09-15 2016-08-01 /pmc/articles/PMC5042611/ /pubmed/27703551 http://dx.doi.org/10.3889/oamjms.2016.082 Text en Copyright: © 2016 Ahmed Atwa, Rehab Hegazy, Nermeen Shaffie, Neamat Yassin, Sanaa Kenawy. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Basic Science Atwa, Ahmed Hegazy, Rehab Shaffie, Nermeen Yassin, Neamat Kenawy, Sanaa Protective Effects of Vasodilatory Βeta-Blockers Carvedilol and Nebivolol against Glycerol Model of Rhabdomyolysis-Induced Acute Renal Failure in Rats |
title | Protective Effects of Vasodilatory Βeta-Blockers Carvedilol and Nebivolol against Glycerol Model of Rhabdomyolysis-Induced Acute Renal Failure in Rats |
title_full | Protective Effects of Vasodilatory Βeta-Blockers Carvedilol and Nebivolol against Glycerol Model of Rhabdomyolysis-Induced Acute Renal Failure in Rats |
title_fullStr | Protective Effects of Vasodilatory Βeta-Blockers Carvedilol and Nebivolol against Glycerol Model of Rhabdomyolysis-Induced Acute Renal Failure in Rats |
title_full_unstemmed | Protective Effects of Vasodilatory Βeta-Blockers Carvedilol and Nebivolol against Glycerol Model of Rhabdomyolysis-Induced Acute Renal Failure in Rats |
title_short | Protective Effects of Vasodilatory Βeta-Blockers Carvedilol and Nebivolol against Glycerol Model of Rhabdomyolysis-Induced Acute Renal Failure in Rats |
title_sort | protective effects of vasodilatory βeta-blockers carvedilol and nebivolol against glycerol model of rhabdomyolysis-induced acute renal failure in rats |
topic | Basic Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042611/ https://www.ncbi.nlm.nih.gov/pubmed/27703551 http://dx.doi.org/10.3889/oamjms.2016.082 |
work_keys_str_mv | AT atwaahmed protectiveeffectsofvasodilatorybetablockerscarvedilolandnebivololagainstglycerolmodelofrhabdomyolysisinducedacuterenalfailureinrats AT hegazyrehab protectiveeffectsofvasodilatorybetablockerscarvedilolandnebivololagainstglycerolmodelofrhabdomyolysisinducedacuterenalfailureinrats AT shaffienermeen protectiveeffectsofvasodilatorybetablockerscarvedilolandnebivololagainstglycerolmodelofrhabdomyolysisinducedacuterenalfailureinrats AT yassinneamat protectiveeffectsofvasodilatorybetablockerscarvedilolandnebivololagainstglycerolmodelofrhabdomyolysisinducedacuterenalfailureinrats AT kenawysanaa protectiveeffectsofvasodilatorybetablockerscarvedilolandnebivololagainstglycerolmodelofrhabdomyolysisinducedacuterenalfailureinrats |