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Hypolipidemic effects of HVC1 in a high cholesterol diet-induced rat model of hyperlipidemia

HVC1, a novel formation containing four herbs, was developed and its hypolipidemic effects in rats with high cholesterol diet (HCD)-induced hyperlipidemia were investigated. The rats were given a HCD for 8 weeks. The HVC1-treated groups were orally administered HVC1 at doses of 10, 50 or 250 mg/kg,...

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Autores principales: Kim, Chae-Yun, Chung, Kyung-Sook, Cheon, Se-Yun, Lee, Kyungjin, Ham, Inhye, Choi, Ho-Young, Cho, Yong Baik, Cho, Byoung-Heon, Mok, So Youn, An, Hyo-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042765/
https://www.ncbi.nlm.nih.gov/pubmed/27510839
http://dx.doi.org/10.3892/mmr.2016.5615
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author Kim, Chae-Yun
Chung, Kyung-Sook
Cheon, Se-Yun
Lee, Kyungjin
Ham, Inhye
Choi, Ho-Young
Cho, Yong Baik
Cho, Byoung-Heon
Mok, So Youn
An, Hyo-Jin
author_facet Kim, Chae-Yun
Chung, Kyung-Sook
Cheon, Se-Yun
Lee, Kyungjin
Ham, Inhye
Choi, Ho-Young
Cho, Yong Baik
Cho, Byoung-Heon
Mok, So Youn
An, Hyo-Jin
author_sort Kim, Chae-Yun
collection PubMed
description HVC1, a novel formation containing four herbs, was developed and its hypolipidemic effects in rats with high cholesterol diet (HCD)-induced hyperlipidemia were investigated. The rats were given a HCD for 8 weeks. The HVC1-treated groups were orally administered HVC1 at doses of 10, 50 or 250 mg/kg, respectively, and the simvastatin group was treated at a dose of 10 mg/kg. The normal diet and HCD control groups were administered with physiological saline. Oral administration of HVC1 (10, 50 or 250 mg/kg) significantly reduced the body weight of rats with hyperlipidemia and regulated the total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels in the serum. In addition, tissue analysis revealed that lipid accumulation in the liver and aorta was reduced by HVC1 administration. Furthermore, HVC1 significantly reduced the mRNA expression of peroxisome proliferator-activated receptor-γ, 3-hydroxy-3-methylglutaryl-CoA reductase and low-density lipoprotein receptor, as well as the protein level of 5′ adenosine monophosphate-activated protein kinase in the liver. The results clearly demonstrate that HVC1 has a potent hypolipidemic effect, and suggest that HVC1 should be evaluated as a potential treatment for hyperlipidemia.
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spelling pubmed-50427652016-10-05 Hypolipidemic effects of HVC1 in a high cholesterol diet-induced rat model of hyperlipidemia Kim, Chae-Yun Chung, Kyung-Sook Cheon, Se-Yun Lee, Kyungjin Ham, Inhye Choi, Ho-Young Cho, Yong Baik Cho, Byoung-Heon Mok, So Youn An, Hyo-Jin Mol Med Rep Articles HVC1, a novel formation containing four herbs, was developed and its hypolipidemic effects in rats with high cholesterol diet (HCD)-induced hyperlipidemia were investigated. The rats were given a HCD for 8 weeks. The HVC1-treated groups were orally administered HVC1 at doses of 10, 50 or 250 mg/kg, respectively, and the simvastatin group was treated at a dose of 10 mg/kg. The normal diet and HCD control groups were administered with physiological saline. Oral administration of HVC1 (10, 50 or 250 mg/kg) significantly reduced the body weight of rats with hyperlipidemia and regulated the total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels in the serum. In addition, tissue analysis revealed that lipid accumulation in the liver and aorta was reduced by HVC1 administration. Furthermore, HVC1 significantly reduced the mRNA expression of peroxisome proliferator-activated receptor-γ, 3-hydroxy-3-methylglutaryl-CoA reductase and low-density lipoprotein receptor, as well as the protein level of 5′ adenosine monophosphate-activated protein kinase in the liver. The results clearly demonstrate that HVC1 has a potent hypolipidemic effect, and suggest that HVC1 should be evaluated as a potential treatment for hyperlipidemia. D.A. Spandidos 2016-10 2016-08-09 /pmc/articles/PMC5042765/ /pubmed/27510839 http://dx.doi.org/10.3892/mmr.2016.5615 Text en Copyright: © Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Kim, Chae-Yun
Chung, Kyung-Sook
Cheon, Se-Yun
Lee, Kyungjin
Ham, Inhye
Choi, Ho-Young
Cho, Yong Baik
Cho, Byoung-Heon
Mok, So Youn
An, Hyo-Jin
Hypolipidemic effects of HVC1 in a high cholesterol diet-induced rat model of hyperlipidemia
title Hypolipidemic effects of HVC1 in a high cholesterol diet-induced rat model of hyperlipidemia
title_full Hypolipidemic effects of HVC1 in a high cholesterol diet-induced rat model of hyperlipidemia
title_fullStr Hypolipidemic effects of HVC1 in a high cholesterol diet-induced rat model of hyperlipidemia
title_full_unstemmed Hypolipidemic effects of HVC1 in a high cholesterol diet-induced rat model of hyperlipidemia
title_short Hypolipidemic effects of HVC1 in a high cholesterol diet-induced rat model of hyperlipidemia
title_sort hypolipidemic effects of hvc1 in a high cholesterol diet-induced rat model of hyperlipidemia
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042765/
https://www.ncbi.nlm.nih.gov/pubmed/27510839
http://dx.doi.org/10.3892/mmr.2016.5615
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