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Notch signaling in cerebrovascular diseases (Review)

The Notch signaling pathway is a crucial regulator of numerous fundamental cellular processes. Increasing evidence suggests that Notch signaling is involved in inflammation and oxidative stress, and thus in the progress of cerebrovascular diseases. In addition, Notch signaling in cerebrovascular dis...

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Detalles Bibliográficos
Autores principales: Cai, Zhiyou, Zhao, Bin, Deng, Yanqing, Shangguan, Shouqin, Zhou, Faming, Zhou, Wenqing, Li, Xiaoli, Li, Yanfeng, Chen, Guanghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042775/
https://www.ncbi.nlm.nih.gov/pubmed/27574001
http://dx.doi.org/10.3892/mmr.2016.5641
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author Cai, Zhiyou
Zhao, Bin
Deng, Yanqing
Shangguan, Shouqin
Zhou, Faming
Zhou, Wenqing
Li, Xiaoli
Li, Yanfeng
Chen, Guanghui
author_facet Cai, Zhiyou
Zhao, Bin
Deng, Yanqing
Shangguan, Shouqin
Zhou, Faming
Zhou, Wenqing
Li, Xiaoli
Li, Yanfeng
Chen, Guanghui
author_sort Cai, Zhiyou
collection PubMed
description The Notch signaling pathway is a crucial regulator of numerous fundamental cellular processes. Increasing evidence suggests that Notch signaling is involved in inflammation and oxidative stress, and thus in the progress of cerebrovascular diseases. In addition, Notch signaling in cerebrovascular diseases is associated with apoptosis, angiogenesis and the function of blood-brain barrier. Despite the contradictory results obtained to date as to whether Notch signaling is harmful or beneficial, the regulation of Notch signaling may provide a novel strategy for the treatment of cerebrovascular diseases.
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spelling pubmed-50427752016-10-05 Notch signaling in cerebrovascular diseases (Review) Cai, Zhiyou Zhao, Bin Deng, Yanqing Shangguan, Shouqin Zhou, Faming Zhou, Wenqing Li, Xiaoli Li, Yanfeng Chen, Guanghui Mol Med Rep Articles The Notch signaling pathway is a crucial regulator of numerous fundamental cellular processes. Increasing evidence suggests that Notch signaling is involved in inflammation and oxidative stress, and thus in the progress of cerebrovascular diseases. In addition, Notch signaling in cerebrovascular diseases is associated with apoptosis, angiogenesis and the function of blood-brain barrier. Despite the contradictory results obtained to date as to whether Notch signaling is harmful or beneficial, the regulation of Notch signaling may provide a novel strategy for the treatment of cerebrovascular diseases. D.A. Spandidos 2016-10 2016-08-19 /pmc/articles/PMC5042775/ /pubmed/27574001 http://dx.doi.org/10.3892/mmr.2016.5641 Text en Copyright: © Cai et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Cai, Zhiyou
Zhao, Bin
Deng, Yanqing
Shangguan, Shouqin
Zhou, Faming
Zhou, Wenqing
Li, Xiaoli
Li, Yanfeng
Chen, Guanghui
Notch signaling in cerebrovascular diseases (Review)
title Notch signaling in cerebrovascular diseases (Review)
title_full Notch signaling in cerebrovascular diseases (Review)
title_fullStr Notch signaling in cerebrovascular diseases (Review)
title_full_unstemmed Notch signaling in cerebrovascular diseases (Review)
title_short Notch signaling in cerebrovascular diseases (Review)
title_sort notch signaling in cerebrovascular diseases (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042775/
https://www.ncbi.nlm.nih.gov/pubmed/27574001
http://dx.doi.org/10.3892/mmr.2016.5641
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AT zhoufaming notchsignalingincerebrovasculardiseasesreview
AT zhouwenqing notchsignalingincerebrovasculardiseasesreview
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