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Notch signaling in cerebrovascular diseases (Review)
The Notch signaling pathway is a crucial regulator of numerous fundamental cellular processes. Increasing evidence suggests that Notch signaling is involved in inflammation and oxidative stress, and thus in the progress of cerebrovascular diseases. In addition, Notch signaling in cerebrovascular dis...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042775/ https://www.ncbi.nlm.nih.gov/pubmed/27574001 http://dx.doi.org/10.3892/mmr.2016.5641 |
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author | Cai, Zhiyou Zhao, Bin Deng, Yanqing Shangguan, Shouqin Zhou, Faming Zhou, Wenqing Li, Xiaoli Li, Yanfeng Chen, Guanghui |
author_facet | Cai, Zhiyou Zhao, Bin Deng, Yanqing Shangguan, Shouqin Zhou, Faming Zhou, Wenqing Li, Xiaoli Li, Yanfeng Chen, Guanghui |
author_sort | Cai, Zhiyou |
collection | PubMed |
description | The Notch signaling pathway is a crucial regulator of numerous fundamental cellular processes. Increasing evidence suggests that Notch signaling is involved in inflammation and oxidative stress, and thus in the progress of cerebrovascular diseases. In addition, Notch signaling in cerebrovascular diseases is associated with apoptosis, angiogenesis and the function of blood-brain barrier. Despite the contradictory results obtained to date as to whether Notch signaling is harmful or beneficial, the regulation of Notch signaling may provide a novel strategy for the treatment of cerebrovascular diseases. |
format | Online Article Text |
id | pubmed-5042775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-50427752016-10-05 Notch signaling in cerebrovascular diseases (Review) Cai, Zhiyou Zhao, Bin Deng, Yanqing Shangguan, Shouqin Zhou, Faming Zhou, Wenqing Li, Xiaoli Li, Yanfeng Chen, Guanghui Mol Med Rep Articles The Notch signaling pathway is a crucial regulator of numerous fundamental cellular processes. Increasing evidence suggests that Notch signaling is involved in inflammation and oxidative stress, and thus in the progress of cerebrovascular diseases. In addition, Notch signaling in cerebrovascular diseases is associated with apoptosis, angiogenesis and the function of blood-brain barrier. Despite the contradictory results obtained to date as to whether Notch signaling is harmful or beneficial, the regulation of Notch signaling may provide a novel strategy for the treatment of cerebrovascular diseases. D.A. Spandidos 2016-10 2016-08-19 /pmc/articles/PMC5042775/ /pubmed/27574001 http://dx.doi.org/10.3892/mmr.2016.5641 Text en Copyright: © Cai et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Cai, Zhiyou Zhao, Bin Deng, Yanqing Shangguan, Shouqin Zhou, Faming Zhou, Wenqing Li, Xiaoli Li, Yanfeng Chen, Guanghui Notch signaling in cerebrovascular diseases (Review) |
title | Notch signaling in cerebrovascular diseases (Review) |
title_full | Notch signaling in cerebrovascular diseases (Review) |
title_fullStr | Notch signaling in cerebrovascular diseases (Review) |
title_full_unstemmed | Notch signaling in cerebrovascular diseases (Review) |
title_short | Notch signaling in cerebrovascular diseases (Review) |
title_sort | notch signaling in cerebrovascular diseases (review) |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042775/ https://www.ncbi.nlm.nih.gov/pubmed/27574001 http://dx.doi.org/10.3892/mmr.2016.5641 |
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